Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2020
Cannabinoids in Medicine: Cancer, Immunity, and Microbial Diseases
Paweł Śledziński, Agnieszka Nowak-Terpiłowska, Joanna ZeylandThis narrative review explores how cannabinoids, including those from plants and those produced naturally by the body, influence health through the endocannabinoid system. The authors describe how these compounds intera…
cancer medicine; cannabinoid receptors; cannabinoids; immune medicine - A++2020
Sensitivity of the Fasciae to the Endocannabinoid System: Production of Hyaluronan-Rich Vesicles and Potential Peripheral Effects of Cannabinoids in Fascial Tissue
Caterina Fede , Carmelo Pirri , Lucia Petrelli, Diego Guidolin , Chenglei Fan, Raffaele De Caro, Carla SteccoThis laboratory study investigated how fascial cells respond to cannabinoids. Researchers isolated fibroblast cells from human fascia lata and treated them with a substance that activates cannabinoid receptor 2. The tre…
fascia; hyaluronan; vesicles; endocannabinoid; agonist; antagonist; inflammation; fibrosis; pain; peripheral effect - B2020
Cellular elements organization in the trachea of mallard (Anas platyrhynchos) with a special reference to its local immunological role
Doaa M Mokhtar, Marwa M HussienThis animal study examined the cellular structure of the trachea (windpipe) in mallard ducks using light and electron microscopy. Researchers found a complex organization of cells that form the first line of defense aga…
Telocytes . Dendritic reticular cells . Immune cells . Mucous glands - A+2020
Role of vitamin K 2 in bone metabolism: a point of view and a short reappraisal of the literature
A Capozzi, G Scambia, S Migliaccio, S LelloThis narrative review examines the role of Vitamin K2 in bone metabolism and its contribution to maintaining skeletal integrity. Vitamin K2 is essential for activating osteocalcin, a key protein that binds calcium to th…
Vitamin K2; bone; fracture; menaquinone; osteoporosis - A+++2020
Healthy fats and exclusion-zone size
Abha Sharma, Gerald H PollackThis study investigated whether healthy fats can contribute to the formation of exclusion-zone (EZ) water, also known as the fourth phase of water. Researchers tested substances such as ghee, coconut oil, and lard to se…
Coconut oil; Exclusion-zone water; Fats; Ghee; Health-promoting function; Lard; UV–VIS spectroscopy - A++2020
Extracellular Vesicles Released From Articular Chondrocytes Play a Major Role in Cell-Cell Communication
Xiaoming Liu, Claire Shortt, Fenglin Zhang, Mariah Q Bater, Mary K Cowman, Thorsten KirschThis narrative review examines the role of extracellular vesicles (EVs) as crucial mediators in cell-to-cell communication. EVs are small, lipid-enclosed particles that transport proteins, lipids, and genetic material t…
articular chondrocytes; catabolic events; chondrogenesis; extracellular vesicles - A++2020
Is the extent of obstetric anal sphincter injury correlated with the severity of fecal incontinence in the long term?
L Luciano, M. Bouvier, K Baumstarck, V VittonThis retrospective study investigated the relationship between the extent of obstetric anal sphincter injury and the severity of long-term fecal incontinence (FI). Researchers analyzed data from 250 women with a mean ag…
Fecal incontinence · Obstetrical anal sphincter injury · Endoanal ultrasonography · 3D high-resolution anorectal manometry · Delivery - A++2020
The potential of cannabidiol in the COVID-19 pandemic
Giuseppe Esposito, Marcella Pesce, Luisa Seguella, Walter Sanseverino, Jie Lu, Chiara Corpetti, Giovanni SarnelliThis scientific hypothesis explores the potential of cannabidiol (CBD) as a supportive treatment during the COVID-19 pandemic. The authors suggest that CBD may down-regulate the receptors the virus uses for cellular ent…
fibrosisCannabinoidsimmune systemCOVID-19anti-inflammatory - A+++2020
Cannabis and cannabidiol (CBD) for the treatment of fibromyalgia
Amnon A Berger, Joseph Keefe, Ariel Winnick, Elasaf Gilbert, Jonathan P Eskander, Cyrus Yazdi, Alan D Kaye, Omar Viswan…This narrative review examines the use of cannabis and cannabidiol (CBD) for treating fibromyalgia, a complex condition that often responds poorly to standard therapies. The authors note that while high-quality randomiz…
CBT; SNRI; SSRI; chronic pain; depression; myalgia. - A2020
Comparison of the therapeutic outcomes between open plantar fascia release and percutaneous radiofrequency ablation in the treatment of intractable plantar fasciitis
Yusong Yuan, Yuan Qian, Hao Lu, Yuhui Kou, Yangbo Xu, Hailin XuThis retrospective study compared two surgical treatments for severe, persistent plantar fasciitis: open plantar fascia release and percutaneous radiofrequency ablation. Researchers analyzed outcomes for 31 patients nea…
Intractable plantar fasciitisOpen plantar fascia releasePercutaneous radiofrequency ablation - A2020
Neuroanatomy, Cranial Nerve 11 (Accessory)
Bruno Bordoni, Ryder R Reed, Prasanna Tadi, Matthew VaracalloThis review article describes the anatomy and function of the 11th cranial nerve, the accessory nerve. This nerve is essential for neck and shoulder movement, controlling key muscles like the trapezius and sternocleidom…
cranial nerve XIaccessory nerve - A++2020
Ultrasound imaging of a scar on the knee: Sonopalpation for fascia and subcutaneous tissues
Carmelo Pirri, Antonio Stecco, Caterina Fede, Raffaele De Caro, Carla Stecco, Levent ÖzçakarPersistent pain from surgical or trauma-related scars is a common and sometimes debilitating problem. In this article, the authors describe the use of ultrasound imaging to provide an objective diagnosis for debilitatin…
fasciapainscarultrasonographyknee