Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2020
Om vikten av att stärka immunförsvaret under covid-19
Mats Humble, Bo Jonsson, Per KågesonThis memo summarizes the state of knowledge on strengthening the immune system in the elderly to better manage COVID-19. The authors focus on findings that highlight the importance of maintaining adequate levels of spec…
VitaminsImmune system - B2020
Bicarbonate use and mortality outcome among critically ill patients with metabolic acidosis: A meta analysis
Kevin Bryan Lo, Veronica Garvia, Jessica M Stempel, Pradhum Ram, Janani RangaswamiThis meta-analysis investigated whether treating critically ill patients with sodium bicarbonate for metabolic acidosis, a condition of excess acid in the blood, affects mortality. The use of bicarbonate in intensive ca…
Bicarbonate; ICU; Meta analysis; Metabolic acidosis; Mortality - A2020
Structural remodelling of the lumbar multifidus, thoracolumbar fascia and lateral abdominal wall perimuscular connective tissues: A cross-sectional and comparative ultrasound study
Christian Lariviére, Richard Preuss, Dany H Gagnon, Hakim Mecheri, Sharon M HenryResearchers used ultrasound to compare soft tissues in the lower back and abdomen of people with and without non-acute low back pain (LBP). They measured the multifidus muscle, the thoracolumbar fascia, and the connecti…
Low back pain; Multifidus fatty/fibrosis infiltration; Perimuscular connective tissues; Sex; Ultrasound imaging. - A2020
The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
Ting-Yun Chen, Xiaoyun Li, Ching-Hsia Hung, Harinath Bahudhanapati, Jiangning Tan, Daniel J Kass, Yingze ZhangThis review article explores the relaxin hormone and its receptor, RXFP1, a signaling pathway known for its ability to soften ligaments and connective tissue. While relaxin shows potent antifibrotic potential in laborat…
RXFP1; alternative splicing; fibrosis; relaxin. - A+++2020
A Closer Look at Anandamide Interaction With TRPV1
Chante Muller, Diane L Lynch, Dow P Hurst, Patricia H ReggioThis study used advanced molecular dynamics simulations to investigate how anandamide, an endocannabinoid, interacts with the TRPV1 ion channel, which is central to pain perception. The researchers observed that anandam…
TRP channels; TRPV1; anandamide; cannabinoids; molecular dynamics - A+2020
Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress
Tao Liu, Nan Li, Yi-Qi Yan, Yan Liu, Ke Xiong, Yang Liu, Qing-Mei Xia, Han Zhang, Zhi-Dong LiuThis narrative review examines how phytoestrogens, plant-derived compounds that mimic human estrogen, may influence skin aging processes. Research suggests these molecules can help counteract the decline in collagen and…
collagen; estrogen; oxidative stress; phytoestrogens; skin aging; water content - A+2020
Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse
Adi Y Weintraub, Hannah Glinter, Naama Marcus-BraunThis narrative review examines the epidemiology and causes of pelvic organ prolapse (POP), a condition affecting many women's quality of life. The authors highlight a discrepancy in prevalence rates, noting that while a…
Epidemiology; Pelvic Organ Prolapse; physiopathology - A++2020
Higher Circulating Cortisol in the Follicular vs. Luteal Phase of the Menstrual Cycle: A Meta-Analysis
Ajna Hamidovic, Kristina Karapetyan, Fadila Serdarevic, So Hee Choi, Tory Eisenlohr-Moul, Graziano PinnaThis meta-analysis investigated how levels of the stress hormone cortisol vary across the menstrual cycle in healthy women. By synthesizing data from multiple high-quality studies, researchers found that cortisol levels…
cortisol; follicular; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-gonadal (HPG) axis; luteal; menstrual cycle - A++2020
Biotensegrity: What is the big deal?
Graham ScarrDetails for this entry have not yet been summarized. The title, "Biotensegrity: What is the big deal?", suggests it is an explanatory or editorial piece about the concept of biotensegrity. Biotensegrity is a model that…
biotensegrity - A+2020
The Rolf Method of Structural Integration and Pelvic Floor Muscle Facilitation: Preliminary Results of a Randomized, Interventional Study
Martyna Kasper-Jedrzejewska, Grzegorz Jedrzejewski, Lucyna Ptaszkowska, Kuba Ptaszkowski, Robert Schleip, Tomasz HalskiThis randomized, interventional study investigated how the Rolf Method of Structural Integration (SI) affects pelvic floor muscle function in healthy women. Thirty-three women were divided into two groups; one received…
pelvic floor muscles; Structural Integration; surface electromyography - A+++2020
Collagen supplementation for skin health: A mechanistic systematic review
Meisam Barati, Masoumeh Jabbari, Roya Navekar, Fariba Farahmand, Reihaneh Zeinalian, Ammar Salehi-Sahlabadi, Nasrin Abb…This systematic review evaluates the impact of collagen supplementation on skin health and aging parameters. By analyzing ten clinical trials, researchers found that oral intake of both intact and hydrolyzed collagen co…
M2-like macrophage; collagen; collagen hydrolysate; oral tolerance; regulatory T cell; skin health. - A+++2020
Do Interventions with Diet or Dietary Supplements Reduce the Disease Activity Score in Rheumatoid Arthritis? A Systematic Review of Randomized Controlled Trials
Josefine Nelson, Helen Sjöblom, Inger Gjertsson, Stine M Ulven, Helen M Lindqvist, Linnea BärebringThis systematic review examined randomized controlled trials to determine if diet or dietary supplements can reduce disease activity in adults with rheumatoid arthritis. The researchers found moderate-strength evidence…
DAS28; Rheumatoid Arthritis; diet