Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2019
A Systematic Review of the Morphology and Function of the Sacrotuberous Ligament
DANIELA ALDABE , NIELS HAMMER, NATASHA A M S FLACK, STEPHANIE J WOODLEYThis systematic review examined existing research on the sacrotuberous ligament (STL) to clarify its anatomy and function. The STL is often implicated in conditions like pelvic girdle pain, but its exact role has been d…
anatomy; pelvis; ligament; review - A2019
Lipedema: friend and foe
Yanira Sanchez-De la Torre, Rita Wadeea, Victoria Rosas, Karen L HerbstLipedema is a chronic disorder characterized by painful, disproportionate fat accumulation in the limbs of women, and is often misdiagnosed as obesity. In this review, researchers examined both the negative ('foe') and…
gynoid fat; hypermobility; lipedema; lymphedema; women - A2019
Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer
Anastasia G Tavianatou, Ilaria Caon, Marco Franchi, Zoi Piperigkou, Devis Galesso, Nikos K KaramanosThis narrative review explores how hyaluronan (HA), a key component of the extracellular matrix, functions differently depending on its molecular size. Large, high-molecular weight HA has different biological properties…
cancer; CD44; cell signaling; hyaluronan; inflammation; pharmacological targeting; RHAMM - A2019
Cranial osteopathy: Obscurantism and Enlightenment
Bruno Bordoni, Bruno Morabito, Marta SimonelliIn this reflective article, the authors discuss the controversial aspects of cranial osteopathy. They address common objections, such as the idea that the cranial bones are immobile in adults and that an operator's hand…
fasciaOsteopathicquantum physicsneurophysiologycranio - A2019
High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
Ling-Hui Zeng, Qing-Mei Wang, Lin-Yi Feng, Yu-Dun Ke, Qian-Zi Xu, An-Yi Wei, Chong Zhang, Rong-Biao YingThis study on breast cancer cells in the lab and in mice explored how different doses of vitamin C affect cancer cell behavior. Researchers found that low and medium doses of vitamin C seemed to encourage cancer cells t…
Breast cancermetastasisTGF-β1Vitamin C - A2019
The plasma membrane as a mechanochemical transducer
Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-CusachsIn this review article, researchers describe how the plasma membrane, the cell's outer boundary, acts as a key sensor for mechanical forces. The membrane senses and responds to physical stresses from its environment, su…
mechanotransductionmechanosensorplasma membranemembrane tension - A2019
Biophysics of Cell-Substrate Interactions Under Shear
Neha Paddillaya, Ashish Mishra, Paturu Kondaiah, Pramod Pullarkat, Gautam I Menon, Namrata GundiahIn this review article, the authors examine how cells adhere to surfaces and respond to mechanical forces. Cells use complex structures called focal adhesions to sense and react to their environment, including forces fr…
mechanotransductionfocal adhesionsstress fibersshear stress and devicesbiophysical models - A2019
Evaluation of the Structure of Myodural Bridges in an Equine Model of Ehlers-Danlos Syndromes
Abigail McElroy, Ann Rashmir, Jane Manfredi, Dodd Sledge, Elizabeth Carr, Edward Stopa, Petra KlingeThis animal study investigated myodural bridges—connective tissue links between small neck muscles and the spinal cord's outer covering (dura mater)—in horses. Researchers compared horses with a genetic connective tissu…
Myodural BridgeEhlers-danlos syndromes - A2019
Anterior capsular abnormality: another important MRI finding for the diagnosis of adhesive capsulitis of the shoulder
Jina Park, Yoon-Hee Choi, Jee Won Chai, Seung Woo Cha, Joo Hee Lim, Chris Hyunchul Jo, Dong Hyun KimThis retrospective study investigated whether abnormalities in the shoulder's anterior joint capsule, seen on MRI scans, can help diagnose adhesive capsulitis (frozen shoulder). Researchers compared MRIs from 29 patient…
Anterior capsular abnormalityAdhesive capsulitis of shoulderAnterior capsular thicknessAnterior capsular abnormal hyperintensity - A2019
Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of heparin-binding EGF-like growth factor
Stephan Thönes, Sandra Rother, Tom Wippold, Joanna Blaszkiewicz, Kanagasabai Balamurugan, Stephanie Moeller, Gloria Rui…This study investigated a new type of hydrogel designed to improve wound healing. Researchers combined collagen and hyaluronan (HA), a natural component of connective tissue, with a growth factor that stimulates skin ce…
Biomimetic material; Extracellular matrix (ECM); Fibroblasts; Heparin-binding epidermal growth factor-like growth factor (HB-EGF); Hyaluronan; Hydrogel; Sulfated hyaluronan; Surface plasmon resonance; Wound healing. - A2019
The myodural bridge complex defined as a new functional structure
Nan Zheng, Beom Sun Chung, Yi-Lin Li, Tai-Yuan Liu, Lan-Xin Zhang, Yang-Yang Ge, Nan-Xing Wang, Zhi-Hong Zhang, Lin Cai…The myodural bridge is a known connective tissue link between the deep suboccipital muscles and the spinal cord's outermost covering, the dura mater. In this anatomical study, researchers examined its precise structure…
Myodural BridgeThree-dimensional visualization modelP45 plastinated slicesSuboccipital region - A2019
Cellular nanoscale stiffness patterns governed by intracellular forces
Nicola Mandriota, Claudia Friedsam, John A Jones-Molina, Kathleen V Tatem, Donald E Ingber, Ozgur SahinCell stiffness is important in many biological processes, but its precise relationship to the forces acting inside the cell has been unclear. In this study, researchers developed a new high-resolution imaging platform t…
Tensegritymechanotransductioncell - cell interaction