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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 385–396 of 427 studies · page 33/36A
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  1. A
    2005

    Mechanical control of tissue growth: Function follows form

    Donald E Ingber

    The full text of this 2005 article has not yet been summarized by our team. The title, "Mechanical control of tissue growth: Function follows form," suggests a focus on how mechanical forces influence the development an…

    fasciamechanotransductionmorphogenesis
  2. A
    2005

    An Introduction to Human Biophoton Emission

    Roeland Van Wijk, Eduard P A Van Wijk

    This narrative review explores biophoton emission, the ultraweak light naturally produced by all living systems, including the human body. The authors compiled and analyzed existing research, which has investigated how…

    acupuncturebiophotonsSkinultraweak photon emissionconsciousness
  3. A
    2005

    Cannabimimetic Effects of Osteopathic Manipulative Treatment

    J M McPartland, A Giuffrida, J King, E Skinner, J Scotter, R E Musty

    In this dual-blind, randomized controlled trial, researchers investigated whether osteopathic manipulative treatment (OMT) could produce cannabis-like effects. Thirty-one healthy subjects received either OMT or a sham t…

    CannabinoidsEndocannabinoidsMyofascial releaseFibromyalgiaMyofascial trigger points
  4. A
    2005

    Cell–Matrix Entanglement and Mechanical Anchorage of Fibroblasts in Three-dimensional Collagen Matrices

    H Jiang, F Grinnell

    Researchers studied how fibroblasts, a key connective tissue cell, behave within a three-dimensional collagen matrix that mimics body tissues. They found the cells' ability to engulf particles (phagocytosis) was reduced…

    fibroblastcollagen matrixcell-matrix addesion
  5. A
    2005

    Active fascial contractility: Fascia may be able to contract in a smooth muscle-like manner and thereby influence musculoskeletal dynamics

    Robert Schleip, Werner Klingler, F Lehmann-Horn

    Fascia is typically viewed as a passive tissue that transmits force from muscles. This paper explores the hypothesis that fascia may also be able to actively contract on its own, similar to smooth muscle. Researchers po…

    fasciaConnective tissueMyofascial releaseMyofibroblastproprioception
  6. A
    2005

    Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo

    H M Langevin, N A Bouffard, G J Badger, J C Iatridis, A K Howe

    In this animal study, researchers investigated how fibroblasts, the primary cells in connective tissue, respond to mechanical stretch. By stretching subcutaneous tissue from mice, both in tissue samples (ex vivo) and in…

    Connective tissueTensegritymechanotransductionmusculoskeletal manipulationsacupuncture
  7. A
    2005

    Cell tension, matrix mechanics, and cancer development

    Sui Huang, Donald E Ingber

    Doctors can often diagnose cancer by feeling for tissue stiffness, and this study explores how this mechanical property contributes to cancer development. The researchers suggest that the stiff extracellular matrix in t…

    extracellular matrixcancercytoskeletonmechanotransduction
  8. A
    2005

    A stromal address code defined by fibroblasts

    G Parsonage, A D Filer, O Haworth, G B Nash, G E Rainger, M Salmon, C D Buckley

    This 2005 review article explores how immune cells (leukocytes) navigate within the body's tissues. The authors propose that fibroblasts create a "stromal address code" that acts as a local guidance system. This code di…

    inflammationfibroblaststromal adress codeleukocyte
  9. A
    2004

    TGF-beta signaling and the fibrotic response

    Andrew Leask, David J Abraham

    This 2004 narrative review discusses the molecular basis of fibrotic diseases, which are characterized by excessive production and deposition of connective tissue. The authors summarize the state of knowledge concerning…

    sclerodermaCTGFSmadMAP kinaseprostacyclin
  10. A
    2004

    Integrins in Mechanotransduction

    Akira Katsumi, A Wayne Orr, Eleni Tzima, Martin Alexander Schwartz

    This 2004 review article examines how cells sense and respond to physical forces, a process known as mechanotransduction. The authors focus on integrins, a class of proteins that anchor cells to their surroundings and a…

    mechanotransductionIntegrins
  11. A
    2004

    Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading

    MICHAEL KJÆR

    This review discusses how the extracellular matrix (ECM), particularly collagen, adapts to mechanical loading in tendons and muscles. Physical activity stimulates both the creation and breakdown of collagen, a process e…

    collagentendonsMechanical loadingECMskeletal muscles
  12. A
    2004

    Fibroblasts form a body-wide cellular network

    Helene M Langevin, Carson J Cornbrooks, Douglas J Taatjes

    In this mouse study, researchers investigated how cells called fibroblasts connect to one another within loose connective tissue. Using various microscopy techniques, they found that fibroblasts form an extensive, web-l…

    Connective tissueSubcutaneous tissueConnexinGap junctionsCell signaling