Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2016
What Is Evidence-Based About Myofascial Chains: A Systematic Review
Jan Wilke, Frieder Krause, Lutz Vogt, Winfried BanzerThis systematic review evaluated anatomical dissection studies to find evidence for six proposed myofascial meridians. Researchers analyzed 62 studies and found strong evidence for the anatomical continuity of three lin…
fasciaForce transmissionmyofascial chainsmeridians - A2016
The tongue after whiplash: case report and osteopathic treatment
Bruno Bordoni, Fabiola Marelli, Bruno MorabitoThis case report describes a 30-year-old man who experienced neck pain during swallowing and had a reduced ability to open his mouth following a whiplash injury. He was treated with osteopathic manual techniques directe…
fasciafascial releasetongueindirect osteopathic techniques - A2016
Human Recombinant Hyaluronidase Injections For Upper Limb Muscle Stiffness in Individuals With Cerebral Injury: A Case Series
Preeti Raghavan, Ying Lu, Mona Mirchandani, Antonio SteccoThis case series investigated injections of the enzyme hyaluronidase to treat upper limb muscle stiffness in 20 individuals with cerebral injury. The researchers hypothesized that an accumulation of hyaluronan in the mu…
fasciaConnective tissueStrokeHypertoniaspasticity - A2015
Primo Vascular System: A Unique Biological System Shifting a Medical Paradigm
Bruno Chikly, Paul Roberts, Jörgen QuaghebeurThis article describes the primo vascular system (PVS), a unique biological system distinct from the arteriovenous and lymphatic systems. Research suggests the PVS has immune and endocrine functions and plays a role in…
fasciaprimo vascular system - A2015
Innervation Changes Induced by Inflammation of the Thoracolumbar Fascia
U Hoheisel, J Rosner, S MenseThis animal study investigated how inflammation affects the nerves in the thoracolumbar fascia (TLF) of rats. Researchers induced inflammation in the TLF and compared its nerve fiber density to that of healthy fascia. W…
inflammationfasciafasciitisfascia innervationsympathetic fibers - A2015
Hyaluronan, inflammation and breast cancer progression
Katryn L Schwertfeger, Mary K Cowman, Patrick G Telmer, Eva A Turley, James B McCarthyThis narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…
hyaluronaninflammationCD44fasciaBreast cancer - A2015
Structural Integration as an Adjunct to Outpatient Rehabilitation for Chronic Nonspecific Low Back Pain: A Randomized Pilot Clinical Trial
Eric E Jacobson, Alec L Meleger, Paolo Bonato, Peter M Wayne, Helene M Langevin, Ted J Kaptchuk, Roger B DavisThis randomized pilot clinical trial investigated if adding Structural Integration (SI) to standard outpatient rehabilitation could help people with chronic non-specific low back pain. Researchers assigned 46 participan…
fascia - A2015
Understanding Fibroblasts in Order to Comprehend the Osteopathic Treatment of the Fascia
Bruno Bordoni, Emiliano ZanierIn this review paper, the authors argue that understanding fibroblasts is essential for comprehending and applying osteopathic treatment of the fascia. As the foundational cells of connective tissue, fibroblasts have ma…
fasciafibroblastosteopathy - A2015
Primo-Vascular System as Presented by Bong Han Kim
Vitaly Vodyanoy, Oleg Pustovyy, Ludmila Globa, Iryna SorokulovaIn the 1960s, researcher Bong Han Kim described a new vascular system, distinct from the blood and lymph systems, which he proposed was involved in tissue regeneration. However, his work was difficult for later scientis…
fasciaprimo vascular system - A2015
Investigation of meningomyovertebral structures within the upper cervical epidural space: a sheet plastination study with clinical implications
Frank Scali, Matthew E Pontell, Lance G Nash, Dennis E EnixThis cadaver study investigated soft-tissue connections within the epidural space of the upper cervical spine using dissection and a technique called sheet plastination. The researchers found consistent connections wher…
fasciacervical spineMyodural Bridgedural lacerationsepidural space - A2015
The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases
James L Oschman, Gaétan Chevalier, Richard BrownThis report summarizes research on the effects of "grounding" or "earthing," which involves direct electrically conductive contact with the Earth's surface. The research suggests this contact may influence the body's ph…
fasciachronic inflammationimmune systemwound repairwhite blood cells - A2015
Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?
S Albeiroti, A Soroosh, C A de la MotteThis 2015 review article explores the role of hyaluronan (HA) in fibrosis, a condition where excessive connective tissue buildup impairs organ function. HA is a key component of the extracellular matrix, known for its h…
hyaluronanfasciafibrosis
