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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 25–28 of 28 studies · page 3/3extracellular matrixA
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  1. A
    2003

    New and active role of the interstitium in control of interstitial fluid pressure: potential therapeutic consequences

    H Wiig, K Rubin, R K Reed

    This review challenges the traditional view of the interstitium as merely a passive fluid reservoir. The researchers present data suggesting that connective tissue cells and the extracellular matrix actively regulate in…

    inflammationextracellular matrixInterstitial fluid volumeintegrins edema
  2. A
    1999

    Tensegrity and mechanoregulation: from skeleton to cytoskeleton

    Christopher S Chen, Donald E Ingber

    This review article explores how mechanical forces are transmitted from the whole body down to individual cells. The authors propose that a design principle called "tensegrity," which uses continuous tension and local c…

    extracellular matrixTensegritycytoskeletonmechanotransductionIntegrins
  3. A
    1997

    Tensegrity: The Architectural Basis of Cellular Mechanotransduction

    D E Ingber

    This 1997 review article proposes a model for how cells sense and respond to physical forces, a process called mechanotransduction. The author suggests that cells are built using 'tensegrity' architecture, a system of b…

    extracellular matrixsignal transductioncytoskeletonIntegrinsmechanoreceptor
  4. A
    1987

    Endothelial Growth Factors and Extracellular Matrix Regulate Dna Synthesis Through Modulation of Cell and Nuclear Expansion

    Donald E Ingber, Joseph A Madri,, Judah Folkman

    This study investigated how the extracellular matrix (ECM) and growth factors work together to regulate the growth of capillary endothelial cells, which line blood vessels. Researchers found that these cells needed both…

    extracellular matrixgrowth factorsnuclear modulationcell modulation