Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesHyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?
This 2015 review article explores the role of hyaluronan (HA) in fibrosis, a condition where excessive connective tissue buildup impairs organ function. HA is a key component of the extracellular matrix, known for its h…
Essential Experimental Methods for Identifying Bonghan Systems as a Basis for Korean Medicine: Focusing on Visual Materials from Original Papers and Modern Outcomes
This narrative review examines methods for identifying the so-called Bonghan system, also known as the primo vascular system (PVS). This system was originally proposed in the 1960s as the anatomical basis for acupunctur…
Primo Vascular System: An Endothelial-to-Mesenchymal Potential Transitional Tissue Involved in Gastric Cancer Metastasis
The primo vascular system (PVS) is described as a distinct circulatory network beyond the blood and lymphatic systems. This study investigated the role this system might play in the spread of gastric cancer. The researc…
Primo-Vascular System as Presented by Bong Han Kim
In the 1960s, researcher Bong Han Kim described a new vascular system, distinct from the blood and lymph systems, which he proposed was involved in tissue regeneration. However, his work was difficult for later scientis…
Evidence for the existence of nociceptors in rat thoracolumbar fascia
This animal study on rats investigated the presence of pain-sensing nerve fibers (nociceptors) in the thoracolumbar fascia. Researchers compared normal fascia with tissue in which they had induced inflammation. The resu…
Comparative effects of vitamin C on the effects of local anesthetics ropivacaine, bupivacaine, and lidocaine on human chondrocytes
Local anesthetics injected into joints can sometimes be harmful to cartilage cells (chondrocytes). This laboratory study investigated the effects of three common anesthetics—ropivacaine, bupivacaine, and lidocaine—on hu…
Collagen network strengthening following cyclic tensile loading
Tissues adapt to the mechanical loads they experience, with collagen being the primary load-bearing component. In this study, researchers investigated how a collagen-based material responded to repeated, cyclic tensile…
Isolated human uterine telocytes: immunocytochemistry and electrophysiology of T-type calcium channels
Telocytes are a relatively newly described cell type found in the muscular wall of the uterus, thought to play a role in cell-to-cell signaling. In this laboratory study, researchers examined telocytes from both pregnan…
Hyaluronan, inflammation and breast cancer progression
This narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…
Pathophysiology and Immune Dysfunction in Endometriosis
This narrative review explores the current understanding of endometriosis, a chronic inflammatory condition affecting many women of reproductive age. The authors focus on how endometriosis lesions develop a blood supply…
Mitochondrial Dysfunction and Disturbed Coherence: Gate to Cancer
This theoretical paper explores the link between cellular energy and cancer. Healthy cells maintain a stable, coherent electrical state through continuous energy production in the mitochondria. The authors propose that…
Primo Vascular System: A Unique Biological System Shifting a Medical Paradigm
This article describes the primo vascular system (PVS), a unique biological system distinct from the arteriovenous and lymphatic systems. Research suggests the PVS has immune and endocrine functions and plays a role in…