Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2015
The content and size of hyaluronan in biological fluids and tissues
Mary K Cowman, Hong-Gee Lee, Kathryn L Schwertfeger, James B McCarthy,, Eva A TurleyHyaluronan is a simple sugar polymer found throughout the body's tissues and fluids. It is typically produced as a very large, high-molecular-mass molecule. This narrative review notes that during processes like inflamm…
hyaluronanfasciaquantificationassaymolecular mass - A2015
Innervation Changes Induced by Inflammation of the Thoracolumbar Fascia
U Hoheisel, J Rosner, S MenseThis animal study investigated how inflammation affects the nerves in the thoracolumbar fascia (TLF) of rats. Researchers induced inflammation in the TLF and compared its nerve fiber density to that of healthy fascia. W…
inflammationfasciafasciitisfascia innervationsympathetic fibers - A2015
Biological electric fields and rate equations for biophotons
M Alvermann, Y N Srivastava, J Swain, A WidomThis theoretical paper explores the relationship between biophotons (light emitted by living organisms) and the electric fields within biological systems. The authors note that biophoton intensity is linked to the stren…
biophotonsElectric fieldsNonlinear rate equations - A2015
The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases
James L Oschman, Gaétan Chevalier, Richard BrownThis report summarizes research on the effects of "grounding" or "earthing," which involves direct electrically conductive contact with the Earth's surface. The research suggests this contact may influence the body's ph…
fasciachronic inflammationimmune systemwound repairwhite blood cells - A2015
New Developments in the Primo Vascular System: Imaging and Functions with regard to Acupuncture
Richard C Niemtzow, Kwang-Sup Soh, Kyung A Kang, John H Barker, He Sheng Luo, Moriya OhkumaThis research entry, for which only the title is available, appears to discuss recent advancements in understanding the primo vascular system. The title suggests a focus on new imaging techniques and the system's functi…
acupunctureprimo vascular systemeditorial - A2015
The fascial system and exercise intolerance in patients with chronic heart failure: hypothesis of osteopathic treatment
Bruno Bordoni, F MarelliThis hypothesis paper proposes a connection between the fascial system and exercise intolerance in people with chronic heart failure. The authors note that heart failure is a complex disease affecting the entire body, l…
fasciaManual TherapyOsteopathicfatiguechronic heart failure - A2015
Remodelling the extracellular matrix in development and disease
Caroline Bonnans, Jonathan Chou, Zena WerbThis narrative review describes the extracellular matrix (ECM), a dynamic network present in all body tissues that undergoes constant remodeling. This remodeling process is crucial for regulating cell functions like pro…
fasciaextracellular matrixstiffnessmechanotransductionmatrix remodeling - A2015
Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review
Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero, María Cruz Pérez-Yus, Marcelo M P Demarzo, Mauro García-Toro, J…This systematic review examined how non-drug treatments affect inflammatory markers in people with fibromyalgia. Researchers analyzed 12 studies involving 536 participants who underwent exercise, dietary, or multidiscip…
fasciaFibromyalgiapaincytokinessleep quality - A2015
Understanding Fibroblasts in Order to Comprehend the Osteopathic Treatment of the Fascia
Bruno Bordoni, Emiliano ZanierIn this review paper, the authors argue that understanding fibroblasts is essential for comprehending and applying osteopathic treatment of the fascia. As the foundational cells of connective tissue, fibroblasts have ma…
fasciafibroblastosteopathy - A2015
Glycosaminoglycans and Proteoglycans in Palmar Fascia of Patients with Dupuytren
Priscilla Carneiro Hirai Nascimento, Elsa Yoko Kobayashi, Luiz Guilherme de Saboya Lenzi, João baptista Gomes dos Santo…In this experimental study, researchers investigated the role of glycosaminoglycans (GAGs), a type of molecule in connective tissue, in Dupuytren's disease. The team analyzed palmar fascia tissue samples from 23 patient…
fasciaProteoglycansdupuytren contractureglycosaminoglycans - A2015
Modelling the mechanoreceptor’s dynamic behaviour
Zhuoyi Song, Robert W Banks, Guy S BewickThis study developed a computational model to better understand how mechanoreceptors, our body's stretch and pressure sensors, adapt to stimuli. Researchers adapted a model originally used for vision in flies to simulat…
fasciabiophysical modelfly photoreceptorrefractory periodsensory adaptation - A2015
Structural Integration as an Adjunct to Outpatient Rehabilitation for Chronic Nonspecific Low Back Pain: A Randomized Pilot Clinical Trial
Eric E Jacobson, Alec L Meleger, Paolo Bonato, Peter M Wayne, Helene M Langevin, Ted J Kaptchuk, Roger B DavisThis randomized pilot clinical trial investigated if adding Structural Integration (SI) to standard outpatient rehabilitation could help people with chronic non-specific low back pain. Researchers assigned 46 participan…
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