Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2017
Calcium Signaling in Interstitial Cells: Focus on Telocytes
Beatrice Mihaela Radu, Adela Banciu, Daniel Dumitru Banciu, Mihai Radu, Dragos Cretoiu, Sanda Maria CretoiuThis narrative review describes current knowledge on calcium signaling in a group of cells called interstitial cells, with a special focus on telocytes. These cells and their calcium signals are important for generating…
telocytesinterstitial cellscalcium signalingCa2+ oscillationspacemaker activity - A2017
Telocytes heterogeneity: From cellular morphology to functional evidence
Dragos Cretoiu, Beatrice Mihaela Radu, Adela Banciu, Daniel Dumitru Banciu, Sanda Maria CretoiuThis review discusses telocytes, a recently identified type of cell found throughout the connective tissue (stroma) of vertebrates. They are characterized by extremely long, thin extensions called telopodes, which form…
cancertelocytesregenerative medicinestem cellsImmunophenotype heterogeneity - A2017
The significance of closed kinematic chains to biological movement and dynamic stability
Stephen Levin, Susan Lowell de Sol!orzano, Graham ScarrBiomechanical research has long focused on the body as a system of levers, but this review highlights the importance of "closed kinematic chains" (CKCs). These are continuous mechanical loops that couple multiple parts…
biotensegrityBiomechanicsClosed-chainDevelopmentEvolution - A2017
Art Advancing Science: Filmmaking Leads to Molecular Insights at the Nanoscale
Charles Reilly, Donald E IngberA project that began as an artistic endeavor to create an entertaining short film about fertilization led to the development of a new scientific simulation tool. By integrating physics-based animation software from the…
Tensegritysimulationanimationaxonemedynein - A2017
Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles
Uma Thanigai Arasu, Riikka Kärnä, Kai Härkönen, Sanna Oikari, Arto Koistinen, Heikki Kröger, Chengjuan Qu, Mikko J Lamm…Mesenchymal stem cells (MSCs) are known to help with tissue repair, partly by releasing tiny packages called extracellular vesicles (EVs). This study investigated the connection between these EVs and hyaluronan (HA), a…
Hyaluronan; CD44; Extracellular vesicle; Stem cell; Filopodia; Hyaluronan synthase - A2017
Rectus Capitis Posterior Minor
Gabriel Venne, Brian J Rasquinha, Manuela Kunz, Randy E EllisThis cadaver study investigated the connection between a small neck muscle (Rectus Capitis Posterior Minor, RCPMi) and the spinal dura mater. Researchers used both microscopic analysis and biomechanical testing to clari…
biomechanical testingcervical dura matermechanical influence of musclesmechanical influence of soft tissuerectus capitis posterior minor - A2016
Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration
Michele M Temple-Wong, Shuwen Ren, Phu Quach, Bradley C Hansen, Albert C Chen, Akihiko Hasegawa, Darryl D D’Lima, Jim K…This study investigated how the lubricant hyaluronan in knee joint fluid changes with age and cartilage wear. Researchers analyzed synovial fluid from human donors aged 23 to 91 without diagnosed osteoarthritis. They fo…
hyaluronanAgingSynovial fluidDegeneration - A2016
The Physical Mechanism for Retinal Discrete Dark Noise: Thermal Activation or Cellular Ultraweak Photon Emission?
Vahid Salari, Felix Scholkmann, Istvan Bokkon, Farhad Shahbazi, Jack TuszynskiThe visual 'static' or 'noise' we perceive in complete darkness has long been a puzzle. The conventional explanation is that random thermal energy causes photoreceptor cells in the retina to fire, but this model doesn't…
Biophotons - A2016
Acute bouts of upper and lower body static and dynamic stretching increase non‑local joint range of motion
David George Behm, Tyler Cavanaugh, Patrick Quigley, Jonathan Christopher Reid, Priscyla Silva Monteiro Nardi, Paulo He…This study investigated whether stretching one part of the body could increase flexibility in a completely different area. Researchers had participants perform either static or dynamic stretches for their shoulders and,…
Crossover fatigue · Non-local muscle fatigue · Flexibility · Range of motion · Strength · Electromyography - A2016
Hyaluronan production and molecular weight is enhanced in pathway-engineered strains of lactate dehydrogenase-deficient Lactococcus lactis
Mandeep Kaur, Guhan JayaramanResearchers are exploring ways to use engineered bacteria to produce hyaluronic acid (HA), but the yield and molecular weight have often been limited. Previous work suggested that excessive lactate production might be t…
Hyaluronic acid molecular weightLactococcus lactisLactate dehydrogenase mutantNADþ/NADH ratioHA-precursor concentration ratio - A2016
Restoration of Full Shoulder Range of Motion After Application of the Fascial Distortion Model
Joshua D Boucher, Jose FigueroaThis case report describes a 28-year-old man with chronic shoulder pain and severely limited movement, 18 months after an injury. His condition, similar to a frozen shoulder, involved significant pain and an inability t…
frozen shoulderfascial distortion modelrange of motion - A2016
Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain
David M Klyne, Mary F Barbe, Paul W HodgesThis study investigated systemic inflammation in acute low back pain, which is less studied than inflammation in chronic conditions. Researchers analyzed blood samples from 99 individuals within two weeks of LBP onset a…
Pro-inflammatory cytokinesC-reactive protein (CRP)Interleukin-6 (IL-6)Tumor necrosis factor (TNF)Interleukin-1beta (IL-1beta)