Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2018
The infrapatellar fat pad and the synovial membrane: an anatomo-functional unit
Veronica Macchi, Elena Stocco, Carla Stecco, Elisa Belluzzi, Marta Favero, Andrea Porzionato, Raffaele De CaroThis descriptive review summarizes evidence on the close relationship between the infrapatellar fat pad and the synovial membrane in the knee. Anatomically, they are linked, as parts of the synovial membrane insert into…
infrapatellar fat pad; knee plicae; osteoarthritis; synovial membrane. - A2018
Fasciae of the musculoskeletal system: normal anatomy and MR patterns of involvement in autoimmune diseases
Thomas Kirchgesner, Xavier Demondion, Maria Stoenoiu, Patrick Durez, Adrien Nzeusseu Toukap, Frédéric Houssiau, Christi…This review article describes the fascial system as a three-dimensional continuum of connective tissue found throughout the body. The authors review the normal anatomy of fascia and its appearance on magnetic resonance…
fasciaMusculoskeletalAnatomyAutoimmuneMRI - A2018
Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study
Won-Young Kim, Eun-Jung Jo, Jung Seop Eom, Jeongha Mok, Mi-Hyun Kim, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Kwangha LeeThis cohort study investigated a combination therapy of vitamin C, hydrocortisone, and thiamine for ICU patients with severe pneumonia. Researchers compared a group receiving the treatment to a control group from the pr…
Ascorbic acidHydrocortisoneIntensive care unitPneumoniaThiamine - A2018
Therapeutic potentials of superoxide dismutase
H YounusThis narrative review explores the therapeutic potential of superoxide dismutases (SODs), a group of enzymes that serve as a crucial antioxidant defense against oxidative stress in the body. The author discusses the rol…
Oxidative stresssuperoxide dismutasetherapeutic effects - A2018
A New Concept of Biotensegrity Incorporating Liquid Tissues: Blood and Lymph
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto CastagnaThis conceptual article proposes an update to the biotensegrity model, which traditionally focuses on the solid structures of the fascial system. The authors argue that "liquid tissues" like blood and lymph should also…
fasciaChiropracticManual TherapyMyofascialOsteopathic - A2018
Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Francesca Cavallaro, David LintonbonIn this review paper, the authors discuss fibromyalgia, a chronic pain condition whose cause remains uncertain. While often linked to changes in the central nervous system, research also points to peripheral nerve damag…
fasciaFibromyalgiapainMyofascialneuropathic pain - A2018
Immediate effects of self-myofascial release on latent trigger point sensitivity: a randomized, placebo-controlled trial
Jan Wilke, Lutz Vogt, Winfried BanzerThis randomized, placebo-controlled trial examined whether foam rolling could immediately reduce sensitivity in latent trigger points. Researchers compared 90 seconds of static compression, dynamic rolling, and a placeb…
fasciaMyofascial painFoam rollingSelf-masage - A2018
Morphometric and dynamic measurements of muscular fascia in healthy individuals using ultrasound imaging: a!summary of the discrepancies and gaps in the current literature
Caterina Fede, Nathaly Gaudreault, Chenglei Fan, Veronica Macchi, Raffaele De Caro, Carla SteccoThis narrative review examined existing research on using ultrasound to measure muscular fascia in healthy people. The authors found that while ultrasound is a useful tool, the research is concentrated on a few specific…
Fascia · Ultrasound imaging · Thickness · Strain · Motion - A2018
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini , Sanna Pasonen-SeppänenAstrocytomas are the most common type of brain tumor in adults. In this retrospective study, researchers investigated hyaluronan, a key component of the brain's extracellular matrix, and its related enzymes in 163 tumor…
hyaluronanHyaluronan synthaseAstrocytomaPrognosisGlioma - A2018
New Proposal to Define the Fascial System
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna, Beatrice Sacconi, Paul MazzuccoIn this proposal, the authors suggest a new definition for the fascial system, noting that a universally accepted one does not yet exist. They argue for including the epidermis (the outer layer of skin) based on functio…
fasciaConnective tissuefibroblastMyofascialSkin - A2018
The anatomical relationships of the tongue with the body system
Bruno Bordoni, Bruno Morabito, Roberto Mitrano, Marta Simonelli, Anastasia ToccafondiIn this review article, the authors examine the tongue's functions and its anatomical connections to the rest of the body. The tongue is not only essential for swallowing, breathing, and speaking, but it also affects po…
fasciadiaphragmphysiotherapytonguespeech therapy - A2017
Muscle strength and stiffness in resistance exercise: Force transmission in tissues
Hans Chaudhry, Bruce Bukiet, Ellen Z Anderson, Jared Burch, Thomas FindleyResearchers used a mathematical model to estimate how forces are transmitted through the quadriceps muscle during isometric resistance exercises. They specifically looked at how knee angle affects muscle stiffness, stre…
Knee muscle strength; Stiffness; Mathematical modeling; Resistance exercise