Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+2014
Dietary Hyaluronic Acid Migrates into the Skin of Rats
Mariko Oe, Koichi Mitsugi, Wataru Odanaka, Hideto Yoshida, Ryosuke Matsuoka, Satoshi Seino, Tomoyuki Kanemitsu, Yasunob…In this animal study, researchers investigated whether orally ingested hyaluronic acid could reach the skin in rats. Using a radio-labeled version of hyaluronic acid, they tracked its path through the body after rats we…
Orally HAHA supplement - A+2014
Cartilage repair using human embryonic stem cell-derived chondroprogenitors
AIXIN CHENG, ZOHER KAPACEE, JIANG PENG, SHIBI LU, ROBERT J LUCAS, TIMOTHY E HARDINGHAM, SUSAN J KIMBERIn this animal study, researchers developed a method to turn human embryonic stem cells into cartilage-forming cells under laboratory conditions. These new cells were then implanted into cartilage defects in the knee jo…
arthritistissue regenerationCell transplantationEmbryonic stem cell - A+2014
Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility
Núria Mallorquí-Bagué, Sarah N Garfinkel, Miriam Engels, Jessica A Eccles, Guillem Pailhez, Antonio Bulbena, Hugo D Cri…This study investigated the connection between joint hypermobility, anxiety, and interoception (the sense of the body's internal state). Researchers confirmed that hypermobility is associated with higher levels of anxie…
anxiety; emotion; functional magnetic resonance imaging (fMRI); interoception; joint hypermobility; psychology. - A+2013
The myofibroblast matrix: implications for tissue repair and fibrosis
Franco Klingberg, Boris Hinz, Eric S WhiteThis review explores the role of myofibroblasts and the extracellular matrix (ECM) in tissue repair and fibrosis. The ECM is not just a passive scaffold for cells, but an active tissue with its own bioactive properties.…
ECM; myofibroblast; fibrosis - A+2013
R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis
Haitao Wang, Tracy A Brennan, Elizabeth Russell, Jung-Hoon Kim, Kevin P Egan, Qijun Chen, Craig Israelite, David C Schu…This animal study on mice investigated how mechanical signals, like vibration, can stimulate bone growth. Researchers identified proteins secreted by mesenchymal progenitor cells (MPCs) in response to vibration. They fo…
Mechanical signals; vibration; R-spondin 1; telomerase; telomere; aging; osteoporosis; mesenchymal stem cells - A+2013
Exercise training initiated in late middle age attenuates cardiac fibrosis and advanced glycation end-product accumulation in senescent rats
Kathryn J Wright, Melissa M Thomas, Andrew C Betik, Darrell Belke, Russell T HeppleThis animal study investigated if exercise started later in life could still benefit the aging heart. Researchers had late middle-aged rats begin treadmill training and continue into old age, comparing them to sedentary…
%BF; AGE; ANOVA; Advanced glycation end-products; Aging; DXA; ECM; ET; Endurance exercise; F344BNF1; Fibrosis; Fischer 344 Brown Norway F1 hybrid rat; GAPDH; Heart; LV; MMP; Matrix metalloproteinases; RT-PCR; TIMP; TTBS; Tris-buffered saline (+0.5% Tween); WGA; advanced glycation end-product; analysis of variance; dual energy X-ray absorptiometry; exercise training; extracellular matrix; glyceraldehyde 3-phosphate dehydrogenase; left ventricle; matrix metalloproteinase; percent body fat; reverse transcription polymerase chain reaction; tissue inhibitor of matrix metalloproteinase; wheat germ agglutinin. - A+2013
The effect of acute exercise on collagen turnover in human tendons: influence of prior immobilization period
L Moerch, J Pingel, M Boesen, M Kjaer, Henning LangbergResearchers investigated how a period of immobility affects the Achilles tendon's response to exercise. In this study, eight healthy men had one leg immobilized for two weeks while the other was used normally. Afterward…
Immobilization ! Power Doppler ! Blood flow velocity ! Procollagen type I N-terminal peptide ! Microdialysis - A+2013
Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies
Guo-Chong Chen, Da-Bing Lu, Zhi Pang, Qing-Fang LiuThis meta-analysis combined data from multiple prospective studies to investigate the link between vitamin C and stroke risk. The researchers found that people with higher dietary intake of vitamin C had a lower risk of…
antioxidants • diet • meta-analysis • prevention • stroke - A+2013
Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects: a possible link between obesity and local tissue inflammation?
N Arngrim, L Simonsen, J J Holst, J BülowResearchers compared lymphatic drainage from abdominal fat tissue in lean and obese men. They measured drainage before and after the men consumed a glucose drink, which mimics the body's response to a meal. In lean men,…
adipose tissue; lymphatic drainage; blood flow; glucose load; obesity; diabetes - A+2013
Local vitamin-C Injection Reduced Tendon Adhesion in a Chicken Model of Flexor Digitorum Profundus Tendon Injury
Leung-Kim Hung, Sai-Chuen Fu, Yuk-Wa Lee, Tsui-Yu Mok, Kai-Ming ChanThis animal study investigated whether vitamin C could reduce scar tissue formation after a tendon injury. Researchers injured a flexor tendon in chickens and then injected either vitamin C or a saline solution at the s…
Vitamin Chealing tendonadhesion - A+2012
Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism
Tyler A Churchward-Venne, Nicholas A Burd, Stuart M PhillipsIn this 2012 review article, the authors discuss how nutrition can regulate muscle protein synthesis, especially when combined with resistance exercise. Consuming protein (amino acids) stimulates muscle building, an eff…
MusclenutritionhypertrophyAnabolic intramuscular signaling - A+2012
The effect of menopause on the skin and other connective tissues
J Calleja-Agius, M BrincatThis narrative review examines how menopause and the resulting decline in estrogen affect the body's connective tissues, particularly the skin. Research suggests that skin collagen levels drop significantly following me…
collagenageingskin tissuemenopauseoestrogen