Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesInterdisciplinarity and mechanobiology
Mechanobiology is an interdisciplinary field that studies how cells sense and respond to mechanical forces in their environment. In this article, pioneers Donald Ingber and Dino Di Carlo discuss how physical forces infl…
The deep fascia and its role in chronic pain and pathological conditions: A review
This narrative review explores the deep fascia, a three-dimensional continuum of connective tissue surrounding muscles, nerves, and blood vessels. The researchers identified five common conditions associated with fascia…
Risk Factors of Postpartum Depression
This literature review examines the risk factors for postpartum depression (PPD), a condition affecting 10–15% of new mothers globally. The research suggests that factors such as a history of psychiatric illness, lack o…
Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation
This narrative review explores the role of Piezo1 ion channels as mechanical sensors that link physical force to chronic inflammation. Piezo1 channels open in response to stimuli like pressure, stretch, and tissue stiff…
Mechanosensing by Piezo1 and its implications for physiology and various pathologies
This narrative review explores Piezo1, a specialized ion channel that senses mechanical pressure and converts it into biological signals within the body. These channels are widely distributed in tissues such as blood ve…
Lifestyle Factors and Their Influence on Rheumatoid Arthritis: A Narrative Review
This narrative review examines how lifestyle factors influence the development and progression of rheumatoid arthritis (RA). Research suggests that smoking, an unhealthy diet, and obesity increase the risk of developing…
Physical Agent Modalities in Early Osteoarthritis: A Scoping Review
This scoping review investigated the role of physical agent modalities in treating early osteoarthritis (EOA). Researchers searched for studies on treatments like TENS, extracorporeal shockwave therapy (ESWT), ultrasoun…
Fascia and Tensegrity The Quintessence of a Unified Systems Conception
This theoretical paper proposes a new way of viewing the human body, moving beyond the traditional mechanical model of parts and levers. The author suggests the body is better understood as a unified system based on ten…
Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobility
This paper describes the protocol for a clinical trial investigating a new therapy for anxiety in people with joint hypermobility. The proposed therapy, called ADAPT, combines bio-behavioral training with cognitive appr…
Beyond bones: The relevance of variants of connective tissue (hypermobility) to fibromyalgia, ME/CFS and controversies surrounding diagnostic classification: an observational study
This observational study investigated the link between hypermobility, fibromyalgia, and ME/CFS. Researchers found a significant overlap in symptoms between fibromyalgia and ME/CFS in the patient group. A large majority…
Fascial or Muscle Stretching? A Narrative Review
In this narrative review, the authors explore what actually happens in the body during stretching. While it's traditionally been assumed that stretching acts on muscles and tendons, this analysis of tissue mechanics sug…
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration
This study investigates how the mechanical environment of the intervertebral disc influences cellular health during disc degeneration. Researchers found that as the central part of the disc (nucleus pulposus) becomes st…