Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2020
Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts
Torsten Lowin, Ren Tingting, Julia Zurmahr, Tim Classen, Matthias Schneider, Georg PongratzThis laboratory study investigated how cannabidiol (CBD) affects synovial fibroblasts, the cells responsible for joint destruction in rheumatoid arthritis. Researchers found that CBD can reduce the viability of these ce…
inflammationfibroblastCannabinoidsrheumatoid arthritissynovia - A+++2020
The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 2
Bruno Bordoni, Stevan Walkowski, Bruno Ducoux, Filippo TobbiThis narrative review, the second in a series, discusses how modern scientific research challenges some of the original concepts of cranial osteopathy. The authors examine the mechanical characteristics of cranial struc…
fasciaManual TherapyOsteopathiccraniocraniosacral - A+++2020
The role of cannabinoids in the treatment of cancer
L Vecera, T Gabrhelik, P Prasil, P StouracThis review article summarizes current knowledge on how cannabinoids and their receptors modulate tumor diseases. Research suggests that cannabinoids may influence cancer progression by stimulating programmed cell death…
cancer; cannabinoid receptor; cannabinoids; oncological diseases cancer treatment - A+++2020
A Potential Involvement of Anandamide in the Modulation of HO/NOS Systems: Women, Menopause, and "Medical Cannabinoids"
Renáta Szabó, Denise Börzsei, Zsuzsanna Szabó, Alexandra Hoffmann, István Zupkó, Dániel Priksz, Krisztina Kupai, Csaba…This animal study using an estrogen-deficient rat model investigated how the endocannabinoid anandamide (AEA) affects cardiovascular health during menopause-like conditions. Researchers found that estrogen loss reduced…
anandamide; cardiovascular system; heme oxygenase; nitric oxide synthase - A+++2020
Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation
Dennis Muñoz Vergara, Lisbeth Berrueta, Colleen Carmody, Xingxing An, Peter M Wayne, Ann Marie Zavacki, Helene M Langev…This animal study used a novel porcine model to investigate how active stretching affects controlled inflammation in the connective tissue of the back. Researchers trained pigs to perform a specific stretch twice daily…
Stretch - A+++2020
Propolis-induced exclusion of colloids: Possible new mechanism of biological action
Magdalena Kowacz, Gerald H PollackThis laboratory study investigates how propolis (bee glue) interacts with water to create an exclusion zone (EZ)—a layer of water that repels solutes and microorganisms. The researchers found that surfaces coated with p…
Colloid-surface repulsion; Exclusion zone; Propolis - A+++2020
Gut Microbiota and Cardiovascular Disease
Marco Witkowski, Taylor L Weeks, Stanley L HazenThis review explores how the gut microbiota influences cardiovascular health through the production of specific metabolic byproducts. Research suggests that the link is not merely associative; certain bacterial metaboli…
atherosclerosis; cardiovascular diseases; gastrointestinal microbiome; thrombosis; vascular diseases - A+++2020
Diet as a Modulator of Intestinal Microbiota in Rheumatoid Arthritis
Eduardo Dourado, Margarida Ferro, Catarina Sousa Guerreiro, João Eurico FonsecaThis narrative review explores how dietary patterns can influence the gut microbiota in individuals with rheumatoid arthritis (RA). Research indicates that RA patients often exhibit significant differences in their inte…
Mediterranean diet; gut microbiota; probiotics; rheumatoid arthritis - A+++2020
Om vikten av att stärka immunförsvaret under covid-19
Mats Humble, Bo Jonsson, Per KågesonThis memo summarizes the state of knowledge on strengthening the immune system in the elderly to better manage COVID-19. The authors focus on findings that highlight the importance of maintaining adequate levels of spec…
VitaminsImmune system - A+++2020
Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women
Cemal Ozemek, Kerry L Hildreth, Patrick J Blatchford, K Joseph Hurt, Rachael Bok, Douglas R Seals, Wendy M Kohrt, Kerri…This randomized pilot study investigated how a single dose of resveratrol or estradiol affects endothelial function in postmenopausal women. The findings suggest that while both substances can improve the blood vessels'…
aerobic exercise; endothelial function; nutraceutical; sex hormones; women - A+++2020
A Closer Look at Anandamide Interaction With TRPV1
Chante Muller, Diane L Lynch, Dow P Hurst, Patricia H ReggioThis study used advanced molecular dynamics simulations to investigate how anandamide, an endocannabinoid, interacts with the TRPV1 ion channel, which is central to pain perception. The researchers observed that anandam…
TRP channels; TRPV1; anandamide; cannabinoids; molecular dynamics - A+++2020
A Review of the Theoretical Fascial Models: Biotensegrity, Fascintegrity, and Myofascial Chains
Bruno Bordoni, Tom MyersIn this review article, the authors discuss three theoretical models used to understand how fascia functions in the body. The biotensegrity model is mechanical and considers the solid fascia, while the fascintegrity mod…
fasciaMyofascialOsteopathicphysiotherapymyofascial chains