Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2020
Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials
Natiele Camponogara Righi, Felipe Barreto Schuch, Angélica Trevisan De Nardi, Caroline Montagner Pippi, Geovana de Alme…This meta-analysis compiled results from 18 randomized clinical trials to investigate the effects of vitamin C supplementation following a single bout of exercise. The researchers found that vitamin C reduced certain ma…
inflammationOxidative stressexerciseathleteAscorbic acid - A+++2020
Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation
Dennis Muñoz Vergara, Lisbeth Berrueta, Colleen Carmody, Xingxing An, Peter M Wayne, Ann Marie Zavacki, Helene M Langev…This animal study used a novel porcine model to investigate how active stretching affects controlled inflammation in the connective tissue of the back. Researchers trained pigs to perform a specific stretch twice daily…
Stretch - A+++2020
A Potential Involvement of Anandamide in the Modulation of HO/NOS Systems: Women, Menopause, and "Medical Cannabinoids"
Renáta Szabó, Denise Börzsei, Zsuzsanna Szabó, Alexandra Hoffmann, István Zupkó, Dániel Priksz, Krisztina Kupai, Csaba…This animal study using an estrogen-deficient rat model investigated how the endocannabinoid anandamide (AEA) affects cardiovascular health during menopause-like conditions. Researchers found that estrogen loss reduced…
anandamide; cardiovascular system; heme oxygenase; nitric oxide synthase - A+++2020
An anatomical comparison of the fasciae of the thigh: A macroscopic, microscopic and ultrasound imaging study
Carmelo Pirri, Caterina Fede, Lucia Petrelli, Diego Guidolin, Chenglei Fan, Raffaele De Caro, Carla SteccoResearchers compared the thigh's fascial layers using three methods: dissection of cadavers, microscopic analysis, and ultrasound imaging of living volunteers. They identified distinct layers, including a superficial fa…
fascia lataImagingThicknessmusculo-skeletal ultrasoundsuperficial fascia - A+++2020
Fasting-mimicking diet plus chemotherapy in breast cancer treatment
Claudio Vernieri, Francesca Ligorio, Emma Zattarin, Licia Rivoltini, Filippo de BraudThis clinical trial investigated whether a fasting-mimicking diet (FMD) combined with chemotherapy could improve outcomes for breast cancer patients. The overall results were negative, meaning the study did not find a s…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; breast cancer - A+++2020
Do Interventions with Diet or Dietary Supplements Reduce the Disease Activity Score in Rheumatoid Arthritis? A Systematic Review of Randomized Controlled Trials
Josefine Nelson, Helen Sjöblom, Inger Gjertsson, Stine M Ulven, Helen M Lindqvist, Linnea BärebringThis systematic review examined randomized controlled trials to determine if diet or dietary supplements can reduce disease activity in adults with rheumatoid arthritis. The researchers found moderate-strength evidence…
DAS28; Rheumatoid Arthritis; diet - A+++2020
Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women
Cemal Ozemek, Kerry L Hildreth, Patrick J Blatchford, K Joseph Hurt, Rachael Bok, Douglas R Seals, Wendy M Kohrt, Kerri…This randomized pilot study investigated how a single dose of resveratrol or estradiol affects endothelial function in postmenopausal women. The findings suggest that while both substances can improve the blood vessels'…
aerobic exercise; endothelial function; nutraceutical; sex hormones; women - A+++2020
The immediate effect of IASTM vs. Vibration vs. Light Hand Massage on knee angle repositioning accuracy and hamstrings flexibility: A pilot study
George A Koumantakis, Eleonora Roussou, Georgios A Angoules, Nikolaos A Angoules, Theodoros Alexandropoulos, Georgia Ma…This pilot study compared the immediate effects of three different soft tissue techniques on the hamstrings of 16 healthy men. The techniques were instrument-assisted soft tissue mobilization (IASTM), vibration massage,…
fasciaproprioceptionMassageMuscle tightness - A+++2020
Continuous Ascorbate Infusions in the Management of Patients with Advanced Colon Cancer
Nina MikirovaThis study analyzed data from a previous clinical trial involving 17 patients with late-stage colon cancer. The patients received continuous intravenous infusions of vitamin C (ascorbate) over 6-8 weeks. Researchers fou…
Vitamin CAscorbic acidcolon cancer - A+++2020
Movement Caused by Electrical Stimulation of the Lumbosacral Region in Standing Horses
Daniela C Riedler, Rebeka R Zsoldos, Matthias Robel, Isabelle D Jobst, Theresia F LickaThis study investigated how electrical stimulation (ES) affects movement in the lower back and pelvis of standing horses compared to manual techniques. While both methods successfully triggered movement in the lumbosacr…
Electrical stimulation; Lumbosacral; Pelvic inclination; Physical therapy; Sacroiliac - A+++2020
Diet as a Modulator of Intestinal Microbiota in Rheumatoid Arthritis
Eduardo Dourado, Margarida Ferro, Catarina Sousa Guerreiro, João Eurico FonsecaThis narrative review explores how dietary patterns can influence the gut microbiota in individuals with rheumatoid arthritis (RA). Research indicates that RA patients often exhibit significant differences in their inte…
Mediterranean diet; gut microbiota; probiotics; rheumatoid arthritis - A+++2020
Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer
Priyanga Selvakumar, Aja Badgeley, Paige Murphy, Hina Anwar, Urvashi Sharma, Katharine Lawrence, Ashakumary Lakshmikutt…This narrative review explores how dietary flavonoids and other polyphenols may influence breast cancer through epigenetic mechanisms. Research suggests that compounds found in green tea, soy, and berries can affect gen…
Epigenetics; breast cancer; chromatin modification; flavonoids; methylation