Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2021
Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice
Beatriz Carmona-Hidalgo, Isabel González-Mariscal, Adela García-Martín, María E Prados, Francisco Ruiz-Pino, Giovanni A…This study investigated Δ9-tetrahydrocannabinolic acid (Δ9-THCA), the non-psychoactive precursor to THC, for its effects on liver fibrosis and inflammation in mice and cell cultures. The researchers found that Δ9-THCA r…
Fibrogenesis; Inflammation; Liver; NAFLD; Δ(9)-THCA - A+++2021
A Systematic Review of Fibromyalgia and Recent Advancements in Treatment: Is Medicinal Cannabis a New Hope?
Hajra Khurshid, Israa A Qureshi, Nasrin Jahan, Terry R Went, Waleed Sultan, Alisha Sapkota, Michael AlfonsoThis systematic review explores the use of medicinal cannabis as a treatment for fibromyalgia, a condition characterized by chronic widespread pain, fatigue, and sleep disturbances. The researchers explain that fibromya…
alternative therapy; cannabinoids; cannabis; chronic pain; fibromyalgia; pharmacotherapy - A+++2021
Implementation Science Methodologies for Complementary and Integrative Health Research
David Clark, Emmeline Edwards, Peter Murray, Helene LangevinThis narrative review from the NCCIH describes the importance of implementation science in bridging the gap between clinical research and real-world medical practice. Even when therapies like acupuncture or yoga are sho…
complementary and integrative health; dissemination research; implementation science. - A+++2021
Dynamic changes of intestinal flora in patients with irritable bowel syndrome combined with anxiety and depression after oral administration of enterobacteria capsules
Qingqing Guo, Hao Lin, Pengcheng Chen, Songlin Tan, Zhiyong Wen, Lijian Lin, Jianquan He, Jianbo Wen, Shiyun LuThis randomized controlled trial investigated the effects of fecal microbiota transplantation (FMT) via oral capsules on patients with diarrhea-predominant IBS (IBS-D) and comorbid anxiety and depression. The findings s…
Diarrheal irritable bowel syndrome; anxiety and depression; bacterial community; fecal microbiota transplantation - A+++2021
Gut Microbiota Extracellular Vesicles as Signaling Molecules Mediating Host-Microbiota Communications
Salma Sultan, Walid Mottawea, JuDong Yeo, Riadh HammamiThis review article discusses how small membrane-bound sacs called microbiota-released extracellular vesicles (MEVs) act as messengers between the gut microbiome and the host body. These vesicles carry a variety of biol…
gut microbiota; gut microbiota-brain axis; microbial metabolites; microbiota extracellular vesicles; microbiota-host communications; molecular signalling - A+++2021
Layers of interstitial fluid flow along a "slit-shaped" vascular adventitia
Hongyi LI, You LYU, Xiaoliang CHEN, Bei LI, Qi HUA, Fusui JI, Yajun YIN, Hua LIIn this animal study on rabbits, researchers investigated how interstitial fluid, the fluid between cells, moves along the outermost layer of blood vessels. Using imaging techniques like MRI and fluorescent dyes, the sc…
Vascular adventitia; Interstitial fluid; Connective tissue; Interfacial zone - A+++2021
Binding of Androgen- and Estrogen-Like Flavonoids to Their Cognate (Non)Nuclear Receptors: A Comparison by Computational Prediction
Giulia D'Arrigo, Eleonora Gianquinto, Giulia Rossetti, Gabriele Cruciani, Stefano Lorenzetti, Francesca SpyrakisThis computational study investigated how six common flavonoids found in fruits and vegetables bind to the body's estrogen and androgen hormone receptors. Using advanced docking simulations, researchers found that subst…
G protein-coupled receptors; androgens; estrogens; flavonoids; genomic action; molecular docking; non-genomic action; nuclear receptors - A+++2021
The Effects of Fecal Microbiota Transplantation on the Symptoms and the Duodenal Neurogenin 3, Musashi 1, and Enteroendocrine Cells in Patients With Diarrhea-Predominant Irritable Bowel Syndrome
Tarek Mazzawi, Magdy El-Salhy, Gülen Arslan Lied, Trygve HauskenThis clinical study investigated how fecal microbiota transplantation (FMT) affects patients with diarrhea-predominant IBS (IBS-D). Researchers analyzed duodenal biopsies to observe changes in stem cells and hormone-pro…
cell densities; duodenum; fecal microbiota transplantation; gut hormones; irritable bowel syndrome; microbiota; neuroendocrine; stem cells - A+++2020
Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women
Jay Jay Thaung Zaw, Peter R C Howe, Rachel H X WongThis randomized controlled trial investigated how daily resveratrol supplementation affects brain health in postmenopausal women over a 12-month period. Participants took either 75 mg of trans-resveratrol twice daily or…
ageing; cerebrovascular function; cognitive decline; menopause; neurovascular coupling; nutraceutical; phytoestrogen; resveratrol - A+++2020
Endocannabinoids release after Osteopathic Manipulative Treatment. A brief review
Andrea Buscemi, Simona Martino, Santi Scirè Campisi, Alessandro Rapisarda, Marinella CocoThis brief review examines how Osteopathic Manipulative Treatment (OMT) may influence the body's endocannabinoid system, which is crucial for pain regulation and emotional well-being. By analyzing existing research, the…
chronic pain; endocannabinoids; hypothalamic-pituitary-adrenal axis; osteopathic manipulative treatment - A+++2020
Propolis-induced exclusion of colloids: Possible new mechanism of biological action
Magdalena Kowacz, Gerald H PollackThis laboratory study investigates how propolis (bee glue) interacts with water to create an exclusion zone (EZ)—a layer of water that repels solutes and microorganisms. The researchers found that surfaces coated with p…
Colloid-surface repulsion; Exclusion zone; Propolis - A+++2020
The role of cannabinoids in the treatment of cancer
L Vecera, T Gabrhelik, P Prasil, P StouracThis review article summarizes current knowledge on how cannabinoids and their receptors modulate tumor diseases. Research suggests that cannabinoids may influence cancer progression by stimulating programmed cell death…
cancer; cannabinoid receptor; cannabinoids; oncological diseases cancer treatment