Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2021
Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
Amrendra Mishra, Hamed Mirzaei, Novella Guidi, Manlio Vinciguerra, Alice Mouton, Marina Linardic, Francesca Rappa, Rosa…This animal study on mice investigated how periodic cycles of a fasting-mimicking diet (FMD) affect health when consuming a high-fat, high-calorie diet. Researchers found that five days of FMD every month reduced the ac…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; high fat diet; cardiovascular disease - A+++2021
Cannabinoids in the landscape of cancer
Nagina Mangal, Simon Erridge, Nagy Habib, Anguraj Sadanandam, Vikash Reebye, Mikael Hans SodergrenThis narrative review explores how cannabinoids—including plant-derived, endogenous, and synthetic versions—interact with cancer in laboratory and animal models. The research suggests that these compounds may inhibit tu…
Cancer; Cannabidiol; Cannabinoid receptors; Cannabinoids; Endocannabinoid system; Tetrahydrocannabinol - A+++2021
A Closer Look at the Cellular and Molecular Components of the Deep/Muscular Fasciae
Caterina Fede, Carmelo Pirri, Chenglei Fan, Lucia Petrelli, Diego Guidolin, Raffaele De Caro, Carla SteccoThis narrative review describes fascia as a complex and dynamic connective tissue network. This network is composed of different cell types, an extracellular matrix, and nerve fibers. Each component plays a specific rol…
fascia; cells; extracellular matrix; nerve - A+++2021
The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors
Hao Lin, Qingqing Guo, Zhiyong Wen, Songlin Tan, Jie Chen, Lijian Lin, Pengcheng Chen, Jianquan He, Jianbo Wen, Ye ChenThis study investigated the effects of fecal microbiota transplantation (FMT) on patients with diarrhea-predominant IBS (IBS-D) who also experience anxiety and depression. The results suggest that FMT may alleviate both…
Anxiety and depression; Fecal microbiota transplantation; Irritable bowel syndrome; Metagenome; Short-chain fatty acids - A+++2021
Psychological and biological resilience modulates the effects of stress on epigenetic aging
Zachary M Harvanek, Nia Fogelman, Ke Xu, Rajita SinhaChronic stress is linked to negative health outcomes, and this study explored its connection to accelerated biological aging. Researchers evaluated 444 adults, measuring their cumulative stress, biological age using an…
AgingStresspsychological morbidityanxityepigenetic - A+++2021
The Molecular Targets of Cannabinoids in the Treatment of Cancer and Inflammation
Alenabi Aylar, Malekinejad HassanThis narrative review examines how cannabinoids influence inflammation and cancer by interacting with the body's endocannabinoid system. The researchers describe how endogenous, plant-derived, and synthetic compounds ta…
Cannabinoids; anti-proliferative effects; apoptosis; cancer; cell proliferation; inflammation - A+++2021
Direct impact of commonly used dietary emulsifiers on human gut microbiota
Sabrine Naimi, Emilie Viennois, Andrew T Gewirtz, Benoit ChassaingThis laboratory study examined how 20 common dietary emulsifiers affect human gut microbiota using an ex vivo model. The researchers found that several additives, particularly carrageenans and various gums, altered bact…
Dietary emulsifier; Gut microbiota; IBD; Intestinal inflammation - A+++2021
Dynamic changes of intestinal flora in patients with irritable bowel syndrome combined with anxiety and depression after oral administration of enterobacteria capsules
Qingqing Guo, Hao Lin, Pengcheng Chen, Songlin Tan, Zhiyong Wen, Lijian Lin, Jianquan He, Jianbo Wen, Shiyun LuThis randomized controlled trial investigated the effects of fecal microbiota transplantation (FMT) via oral capsules on patients with diarrhea-predominant IBS (IBS-D) and comorbid anxiety and depression. The findings s…
Diarrheal irritable bowel syndrome; anxiety and depression; bacterial community; fecal microbiota transplantation - A+++2020
Movement Caused by Electrical Stimulation of the Lumbosacral Region in Standing Horses
Daniela C Riedler, Rebeka R Zsoldos, Matthias Robel, Isabelle D Jobst, Theresia F LickaThis study investigated how electrical stimulation (ES) affects movement in the lower back and pelvis of standing horses compared to manual techniques. While both methods successfully triggered movement in the lumbosacr…
Electrical stimulation; Lumbosacral; Pelvic inclination; Physical therapy; Sacroiliac - A+++2020
Low-frequency mechanical vibration induces apoptosis of A431 epidermoid carcinoma cells
Wresti L Anggayasti, Chikahiro Imashiro, Taiki Kuribara, Kiichiro Totani, Kenjiro TakemuraResearchers are exploring mechanical vibration as a potential cancer therapy that avoids harming healthy cells. In this lab study, a brief, low-frequency vibration was applied to a line of human skin cancer cells (A431)…
apoptosismechanical vibrationcancer cell modelglucose metabolismhigh-mobility group box 1 - A+++2020
Propolis-induced exclusion of colloids: Possible new mechanism of biological action
Magdalena Kowacz, Gerald H PollackThis laboratory study investigates how propolis (bee glue) interacts with water to create an exclusion zone (EZ)—a layer of water that repels solutes and microorganisms. The researchers found that surfaces coated with p…
Colloid-surface repulsion; Exclusion zone; Propolis - A+++2020
Vitamin D insufficiency as a potential culprit in critical COVID-19 patients
Ruhul Munshi, Mohammad H Hussein, Eman A Toraih, Rami M Elshazli, Christina Jardak, Nasrin Sultana, Mohanad R Youssef,…In this systematic review, researchers analyzed data from six studies to explore the association between vitamin D levels and COVID-19 severity. They found that patients with a poor prognosis had significantly lower ser…
meta-analysisCOVID-19SARS-CoV-2vitamin Doutcome