Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2021
Resveratrol Ameliorates Aortic Calcification in Ovariectomized Rats via SIRT1 Signaling
Sally K Hammad, Rana G Eissa, Mohamed A Shaheen, Nahla N YounisThis animal study on rats investigated how the phytoestrogen resveratrol affects aortic calcification following menopause. Researchers found that resveratrol, similar to estrogen, reduced calcium deposition in arterial…
SIRT1; estrogen; menopause; phytoestrogen; polyphenol; resveratrol; vascular calcification - A+++2021
Estrogenic Effect of Salvia officinalis Extract on Reproductive Function of Female Mice and Identification of Its Phenolic Content
Sabah H Elgayed, Elham A Afify, Hanan A Amin, Ahmed A H AbdellatifThis animal study on mice investigated whether sage (Salvia officinalis) extract could serve as a natural alternative to estrogen replacement therapy. Researchers found that sage contains phytoestrogens, specifically qu…
Natural phytoestrogens; female mice.; menopause; natural estrogen; phenolic content; saliva officinalis; uterotrophic activity - A+++2021
Evidence of a new hidden neural network into deep fasciae
Caterina Fede, Lucia Petrelli, Diego Guidolin, Andrea Porzionato, Carmelo Pirri, Chenglei Fan, Raffaele De Caro, Carla…In this study on mice, researchers examined the nerve networks within two different types of deep fascia: the thoracolumbar fascia (in the lower back) and the gluteal fascia (around the buttock muscles). They found that…
deep fasciainnervation of fascia. low back pain - A+++2021
Soft Tissue Manipulation May Attenuate Inflammation, Modulate Pain, and Improve Gait in Conscious Rodents With Induced Low Back Pain
M Terry Loghmani, Carolyn Tobin, Colleen Quigley, Alanna FennimoreThis animal study on rodents explored how instrument-assisted soft tissue manipulation (IASTM) affects pain, gait, and inflammation in cases of low back pain. The researchers found that the treatment suggests an ability…
rehabilitation - A+++2021
An acupoint-originated human interstitial fluid circulatory network
HongYi Li, Fang Wang, Min Chen, Zhi-Jian Zheng, Ya-Jun Yin, Jun Hu, Hua Li, Andreas Sammer, Georg Feig, Norbert Maurer,…Details from this study have not yet been summarized. The study's title is "An acupoint-originated human interstitial fluid circulatory network". This title suggests the authors are proposing a circulatory network for i…
meridiansacupointsinterstitium - A+++2021
Cannabinoids in Breast Cancer: Differential Susceptibility According to Subtype
Cristina Ferreira Almeida, Natércia Teixeira, Georgina Correia-da-Silva, Cristina AmaralThis narrative review explores how different subtypes of breast cancer respond to cannabinoids like THC and CBD. Research suggests that estrogen receptor-negative cells may be more susceptible to these compounds than ho…
Cannabis sativa; anandamide; breast cancer; cannabidiol; cannabidivarin; cannabigerol; cannabinoids; cannabinol; Δ9-tetrahydrocannabinol - A+++2021
Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
Amrendra Mishra, Hamed Mirzaei, Novella Guidi, Manlio Vinciguerra, Alice Mouton, Marina Linardic, Francesca Rappa, Rosa…This animal study on mice investigated how periodic cycles of a fasting-mimicking diet (FMD) affect health when consuming a high-fat, high-calorie diet. Researchers found that five days of FMD every month reduced the ac…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; high fat diet; cardiovascular disease - A+++2021
Vitamins, the gut microbiome and gastrointestinal health in humans
Van T Pham, Susanne Dold, Ateequr Rehman, Julia K Bird, Robert E SteinertThis narrative review explores how various vitamins influence the gut microbiome and gastrointestinal health in humans. The research suggests that vitamins such as A, B, C, D, and E may increase the diversity of benefic…
Gastrointestinal health; Gut; Gut barrier function; Microbiome; Micronutrient; Vitamins - A+++2021
Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity
Nicholas V DiPatrizioThis narrative review explores how the endocannabinoid system in the upper gastrointestinal tract regulates gut-brain communication to control food intake and energy balance. Research suggests that these lipid-derived s…
CB1 receptor; endocannabinoid; food intake; gut-brain; intestine; reward - A+++2021
Psychological and biological resilience modulates the effects of stress on epigenetic aging
Zachary M Harvanek, Nia Fogelman, Ke Xu, Rajita SinhaChronic stress is linked to negative health outcomes, and this study explored its connection to accelerated biological aging. Researchers evaluated 444 adults, measuring their cumulative stress, biological age using an…
AgingStresspsychological morbidityanxityepigenetic - A+++2021
The Molecular Targets of Cannabinoids in the Treatment of Cancer and Inflammation
Alenabi Aylar, Malekinejad HassanThis narrative review examines how cannabinoids influence inflammation and cancer by interacting with the body's endocannabinoid system. The researchers describe how endogenous, plant-derived, and synthetic compounds ta…
Cannabinoids; anti-proliferative effects; apoptosis; cancer; cell proliferation; inflammation - A+++2021
Potential Nociceptive Role of the Thoracolumbar Fascia: A Scope Review Involving In Vivo and Ex Vivo Studies
Larissa Sinhorim, Mayane Dos Santos Amorim, Maria Eugênia Ortiz, Edsel Balduino Bittencourt, Gianluca Bianco, Fabiana C…This scoping review compiles research on how the thoracolumbar fascia (TLF) in the lower back contributes to pain perception. By examining both animal and human studies, the authors find that the fascia is richly suppli…
ex vivo; fascia; in vivo; innervation; lower back pain; nociceptor; pain; scoping review; thoracolumbar fascia