Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2017
Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation
Benoit Chassaing, Tom Van de Wiele, Jana De Bodt, Massimo Marzorati, Andrew T GewirtzThis study investigated how common food additives, specifically the emulsifiers polysorbate 80 (P80) and carboxymethylcellulose (CMC), affect the gut microbiota. Using a laboratory model of the human intestinal ecosyste…
INFLAMMATION; INTESTINAL MICROBIOLOGY - A+++2017
Activation of type 2 cannabinoid receptor (CB2R) by selective agonists regulates the deposition and remodelling of the extracellular matrix
Tao Guan, Guiyang Zhao, Honghui Duan, Yang Liu, Feng ZhaoThis in vitro study investigated how activating the type 2 cannabinoid receptor (CB2R) affects scar formation in eye connective tissue after surgery. Researchers found that human Tenon’s fibroblasts express these recept…
Matrix metalloproteinase 1 (MMP-1); Tenon’s fibroblasts; Transforming growth factor-β1; Type 2 cannabinoid receptor (CB2R); Wound healing - A+++2017
Early versus Delayed Rehabilitation after Acute Muscle Injury
Monika L Bayer, Peter Magnusson, Michael KjaerThis research entry, titled "Early versus Delayed Rehabilitation after Acute Muscle Injury," is currently awaiting a detailed summary. The title suggests it explores the optimal timing for starting rehabilitation follow…
Rehabilitationmuscle injurymechanical loading in rehabilitation - A+++2017
Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study
John F Pearson, Juliet M Pullar, Renee Wilson, Janet K Spittlehouse, Margreet C M Vissers, Paula M L Skidmore, Jinny Wi…This cohort study examined vitamin C status in 404 fifty-year-olds in New Zealand. Researchers measured the concentration of vitamin C in participants' blood plasma as well as their dietary intake. The results showed th…
ascorbate; cognition; HbA1c; insulin; glucose; hypovitaminosis C - A+++2017
Role of Magnesium in Vitamin D Activation and Function
Anne Marie Uwitonze, Mohammed S RazzaqueIn this scientific review, the authors discuss how magnesium and vitamin D work together in the body. Magnesium acts as a cofactor, meaning it helps activate the enzymes that metabolize vitamin D in the liver and kidney…
Vitamin D activationmagnesiumcalcidefiolcalcitriol - A+++2017
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
Chia-Wei Cheng, Valentina Villani, Roberta Buono, Min Wei, Sanjeev Kumar, Omer H Yilmaz, Pinchas Cohen, Julie B Sneddon…This study, involving mice and human pancreatic cells, explores how cycles of a fasting-mimicking diet (FMD) may influence the pancreas's ability to produce insulin. Researchers found that the diet appears to activate g…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; diabetes - A+++2017
The deep fascia and retinacula of the equine forelimb - structure and innervation
Aleksandra Skalec, Monika EgerbacherThis study investigated the deep fascia and its reinforcements (retinacula) in the equine forelimb using anatomical dissection and microscopic analysis. The researchers found that horse fascia is structurally similar to…
equine; fascia; forelimb; innervation; retinaculum; structure - A+++2017
Resveratrol supplementation reduces pain experience by postmenopausal women
Rachel H X Wong, Hamish M Evans, Peter R C HoweThis randomized, double-blind, placebo-controlled study investigated whether resveratrol supplementation could reduce pain and improve well-being in postmenopausal women. Over 14 weeks, participants taking 75 mg of resv…
Resveratrolpolyphenolemenopause - A+++2017
Therapeutic effectiveness of instrument-assisted soft tissue mobilization for soft tissue injury: mechanisms and practical application
Jooyoung Kim, Dong Jun Sung, Joohyung LeeThis narrative review explores the mechanisms and practical use of Instrument-Assisted Soft Tissue Mobilization (IASTM) for treating soft tissue injuries. IASTM involves using specialized tools to apply mechanical press…
Injury; Instrument-assisted soft tissue mobilization; Pain; Range of motion; Soft tissue function. - A+++2017
Proinflammatory Cytokines and Oxidative Stress Decrease the Transport of Dopamine Precursor Tyrosine in Human Fibroblasts
Ravi Vumma, Jessica Johansson, Nikolaos VenizelosThis laboratory study investigated how inflammation and oxidative stress affect the transport of the amino acid tyrosine in human fibroblasts, a type of connective tissue cell. Tyrosine is a crucial precursor for the ne…
Dopamine precursor; Human fibroblasts; Neuropsychiatric disorders; Oxidative stress; Proinflammatory cytokines; Tyrosine transport. - A+++2017
Electric Nutrition: The Surprising Health and Healing Benefits of Biological Grounding (Earthing)
Stephen T Sinatra, James L Oschman, Gaétan Chevalier, Drew SinatraThis narrative review summarizes research on grounding (earthing), which involves direct physical contact with the Earth's surface. The authors suggest that grounding may provide a form of "electric nutrition" with pote…
Grounding - A+++2016
Nutraceutical supplement in the management of tendinopathies: a systematic review
Federico Fusini, Salvatore Bisicchia, Carlo Bottegoni, Antonio Gigante, Fabio Zanchini, Alberto BusilacchiThis systematic review examines the effects of various nutraceuticals, such as glucosamine, chondroitin, vitamin C, and curcumin, in managing tendon disorders. While preclinical research on cells and animals shows promi…
arginine alpha-keto-glutarate; ascorbate; boswellic acid; curcumin; oral supplement; tendon disorder