Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studiesMechanical stimulation of human dermal fibroblasts regulates pro-inflammatory cytokines: potential insight into soft tissue manual therapies
This lab study investigated how mechanical forces, similar to those in manual therapy, affect human skin cells. Researchers first applied a repetitive strain to cultured dermal fibroblasts to simulate an overuse injury,…
A Potential Involvement of Anandamide in the Modulation of HO/NOS Systems: Women, Menopause, and "Medical Cannabinoids"
This animal study using an estrogen-deficient rat model investigated how the endocannabinoid anandamide (AEA) affects cardiovascular health during menopause-like conditions. Researchers found that estrogen loss reduced…
Cannabis and cannabidiol (CBD) for the treatment of fibromyalgia
This narrative review examines the use of cannabis and cannabidiol (CBD) for treating fibromyalgia, a complex condition that often responds poorly to standard therapies. The authors note that while high-quality randomiz…
Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women
This randomized pilot study investigated how a single dose of resveratrol or estradiol affects endothelial function in postmenopausal women. The findings suggest that while both substances can improve the blood vessels'…
Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women
This randomized controlled trial investigated how daily resveratrol supplementation affects brain health in postmenopausal women over a 12-month period. Participants took either 75 mg of trans-resveratrol twice daily or…
Continuous Ascorbate Infusions in the Management of Patients with Advanced Colon Cancer
This study analyzed data from a previous clinical trial involving 17 patients with late-stage colon cancer. The patients received continuous intravenous infusions of vitamin C (ascorbate) over 6-8 weeks. Researchers fou…
The immediate effect of IASTM vs. Vibration vs. Light Hand Massage on knee angle repositioning accuracy and hamstrings flexibility: A pilot study
This pilot study compared the immediate effects of three different soft tissue techniques on the hamstrings of 16 healthy men. The techniques were instrument-assisted soft tissue mobilization (IASTM), vibration massage,…
Overview of the possible role of vitamin C in management of COVID-19
In this 2020 review, the authors examine the possible role of vitamin C in managing COVID-19. They note that the body's vitamin C levels often drop during an acute infection due to increased metabolic demands. Because v…
The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 1
In this review article, the first of a two-part series, the authors examine the foundational assumptions of cranial osteopathy. They argue that a theoretical model must evolve with new scientific information to avoid be…
A Closer Look at Anandamide Interaction With TRPV1
This study used advanced molecular dynamics simulations to investigate how anandamide, an endocannabinoid, interacts with the TRPV1 ion channel, which is central to pain perception. The researchers observed that anandam…
Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer
This narrative review explores how dietary flavonoids and other polyphenols may influence breast cancer through epigenetic mechanisms. Research suggests that compounds found in green tea, soy, and berries can affect gen…
Movement Caused by Electrical Stimulation of the Lumbosacral Region in Standing Horses
This study investigated how electrical stimulation (ES) affects movement in the lower back and pelvis of standing horses compared to manual techniques. While both methods successfully triggered movement in the lumbosacr…