Topics: Alzheimer’s disease; astaxanthin; neurodegeneration; nutraceuticals; oxidative stress; superoxide dismutase (SOD)
2021; The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review
Topics: Fat free mass; Gelatin; Joint health; Joint pain; Muscle damage; Protein
Topics: Vitamins; minerals; nutrition; nutrients; treatment; mental health
2021; Estrogenic Effect of Salvia officinalis Extract on Reproductive Function of Female Mice and Identification of Its Phenolic Content
Topics: Natural phytoestrogens; female mice.; menopause; natural estrogen; phenolic content; saliva officinalis; uterotrophic activity
Topics: CB1 receptor; endocannabinoid; food intake; gut-brain; intestine; reward
2021; Binding of Androgen- and Estrogen-Like Flavonoids to Their Cognate (Non)Nuclear Receptors: A Comparison by Computational Prediction
Topics: G protein-coupled receptors; androgens; estrogens; flavonoids; genomic action; molecular docking; non-genomic action; nuclear receptors
Topics: COVID-19, meta!analysis, outcome, SARS-CoV-2, vitamin D
Topics: COVID-19; SARS-CoV-2; coronavirus; vitamin C; ascorbate; colds; pneumonia; sepsis; immunonutrition; supplementation
Topics: Vitamin D, COVID-19
Topics: ageing; cerebrovascular function; cognitive decline; menopause; neurovascular coupling; nutraceutical; phytoestrogen; resveratrol
2020; Role of vitamin K 2 in bone metabolism: a point of view and a short reappraisal of the literature
Topics: Vitamin K2; bone; fracture; menaquinone; osteoporosis
2020; Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19
Topics: COVID-19; SARS-CoV-2; Vitamin C; Immune response; In!ammation
2020; Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial
Topics: AGING; CLINICAL TRIALS; DXA; MENOPAUSE; NUTRITION
2020; Perspective: Vitamin D deﬁciency and COVID-19 severity –plausibly linked by latitude, ethnicity, impacts on cytokines,ACE2 and thrombosis
Topics: vitamin D, COVID-19, cytokine
Topics: Vitamin C, COVID-19, SARS-CoV-2, Beneficial effects, Management
2020; Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections
Topics: immune system; viral infection; influenza; COVID-19; micronutrients; vitamins; omega-3 fatty acids; minerals; vitamin C; vitamin D
2020; Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19
Topics: COVID-19; infectious disease; selenium; virus; vitamin C; vitamin D
Topics: vitamin C, corticosteroids, stress respons
2020; Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths
Topics: acute respiratory distress syndrome (ARDS); ascorbic acid; cathelicidin; coronavirus; COVID-19; cytokine storm; influenza; observational; pneumonia; prevention; respiratory tract infection; solar radiation; treatment; UVB; vitamin C; vitamin D
2020; Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials
Topics: Ascorbic acid, Athlete, Exercise, Healthy volunteers, Inflammation, Oxidative stress
2020; Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women
Topics: aerobic exercise; endothelial function; nutraceutical; sex hormones; women
Topics: Vitamin C, ascorbic acid, colon cancer
2020; Ascorbate as Prophylaxis and Therapy for COVID-19—Update From Shanghai and U.S. Medical Institutions
Topics: public health, global health, covid-19, intravenous ascorbate
Topics: Vitamin C, ascorbic acid, antiviral effects,
2020; A Novel Role of Ascorbic Acid in Anti-Inflammatory Pathway and ROS Generation in HEMA Treated Dental Pulp Stem Cells
Topics: human dental pulp stem cells; hema; ascorbic acid; nfkb; erk; perk; inflammatory cytokines
Topics: vitamin C, covid-19, corona virus, high-dose C
Topics: exercise, jumper’s knee, loading, rehabilitation, tendon
2019: Rehabilitation and nutrition protocols for optimising return to play from traditional ACL reconstruction in elite rugby union players: A case study
Topics: ACL, collagen, rehabilitation, nutrition
2019: Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans
Topics: Nutrition, tissue protein synthesis rate, amino acid content in tissues
2019: Plasma Amino Acid Concentrations After the Ingestion of Dairy and Collagen Proteins, in Healthy Active Males
Topics: leucine, proline, glycine, hydroxyproline, tendon, ligament, connective tissue, athlete
2019: Intra-articular effects of combined xenogenous serum rich in growth factors (SRGF) and vitamin C on histopathology grading and staging of osteoarthritis in rat model
Topics: Osteoarthritis; SRGF; Monosodium iodoacetate; Vitamin C; Histopathology
Topics: gelatin, N-terminal peptide of procollagen, exercise, musculoskeletal, injury
Topics: Inflammation, omega-3, curcumin
Topics: Sepsis; vitamin C; HPA axis; stress response
2019; Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2
Topics: F-actin; HIF-1α; YAP1; hippo pathway; lamellipodia; metastasis; synaptopodin 2; triple-negative breast cancer; vitamin C.
Topics: antioxidants; burns; artificial respiration; cardiac surgical procedures; cardiovascular system; critical care; dietary supplements; oxidative stress; sepsis; systematic review
Topics: vitamin C; ascorbic acid; neutrophils; polymorphonuclear leukocytes; migration; chemotaxis; apoptosis; phagocytosis; oxidative burst; systematic review
Topics: Vitamin C, ascorbic acid, sepsis
Topics: Vitamin C, Cortisol, Stress response
2019; Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial
Topics: body composition; collagen peptides; hand-grip strength; leg press; premenopausal; protein supplementation; resistance training
2019; Oral Supplementation of Specific Collagen Peptides Combined with Calf-strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients
Topics: achilles tendon; microvessels; contrast-enhanced ultrasound; hydrolysed collagen supplementation
Topics: gut microbiota; gut microbiome; intestinal microbiome; ketogenic diet; ketogenic diet and fat
2019; High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
Topics: vitamin C, metastasis, TGF-!1, breast cancer
Topics: glucose transporter; vitamin C; gulono-lactone-oxidase; vitamin C recycling
2019; Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience
Topics: Vitamin D, Intact parathyroid hormone, Long-term supplementation, Adverse events
2019; Bone Broth Unlikely to Provide Reliable Concentrations of Collagen Precursors Compared With Supplemental Sources of Collagen Used in Collagen Research
Topics: gelatine; glycine; ligament; proline; protein; tendon
Topics: Ascorbic acid; Cancer treatment; Epigenetics; Hematological malignancies; Vitamin C
Topics: Oxidative stress, superoxide dismutase, therapeutic effects
2018; Pathobiology of cigarette smoke-induced invasive cancer of the renal pelvis and its prevention by vitamin C
Topics: Invasive cancer of the renal pelvis
Persistent EGFR signaling
Cell cycle deregulation
Topics: Metabolic acidosis, Unmeasured anions, Strong ion difference, Strong ion gap, Anion gap Base excess
2018; Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability
Topics: Ankle sprain, collagen, nutrition, ligaments
Topics: Sepsis, Severe sepsis, Sepsis management, Vitamin C, Ascorbic acid, Meta-analysis
2018; Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study
Topics: Ascorbic acid, Hydrocortisone, Intensive care unit, Pneumonia, Thiamine
Topics: Vitamin C, ascorbate, cancer, pharmacokinetics
2017: Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis
Topics: bone, exercise, ligament, tendon, inury prevention, return to play
Topics: training, minimizing injury, return to play, supplementation
2017; Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study
Topics: ascorbate; cognition; HbA1c; insulin; glucose; hypovitaminosis C
2017; Vitamin C for preventing atrial fibrillation in high risk patients: a systematic review and meta-analysis
Topics: Ascorbic acid, Arrhythmia, Antioxidant, Atrial fibrillation, Cardiac surgery, Cardioversion, Intensive care
2017; Theoretical study of aerobic vitamin C loss kinetics during commercial heat preservation and storage
Topics: Ascorbic acid; Degradation reactions; Dehydroascorbic acid; Kinetics; Storage; Thermal processing.
Topics: Vitamin D activation, magnesium, calcidefiol, calcitriol
2017; Resveratrol Treatment Normalizes the Endothelial Function and Blood Pressure in Ovariectomized Rats
Topics: resveratrol, blood pressure, postmenopause
Topics: OVX; Ovariectomy; Resveratrol; Soya free diet
2017; Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer’s disease and a novel protective role for ascorbate
Topics: Alzheimer’s disease; mitochondria; oxidative stress; ascorbate; energy production
2017; Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice
Topics: chronological aging; collagen hydrolysates; histological structure; oxidative stress; skin condition; visual appearance
2017; Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes
Topics: Intensive care, Vitamin C, Hypovitaminosis C, Sepsis, Critical illness, C-reactive protein, Enteral nutrition, Parenteral nutrition, Septic shock
2017; Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study
Topics: corticosteroid; hydrocortisone; septic shock; thiamine; vitamin C
2017; Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
Topics: Vitamin C, insulin resistens, glycaemic control
2017; Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons
Topics: Tendon; Decorin; Biglycan; Collagen fibril; Fiber realignment; Structure; Mechanical properties; Conditional knockout mice
2016: Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways
Topics: chondrocyte; interleukin; matrix metalloproteinase; osteoarthritis; vitamin C
2016: Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome
Topics: Myalgic encephalomyelitis, Chronic fatigue syndrome, Inflammation, Lipopolysaccharides, Microbiome, Microbial translocation, Beta-diversity
2016; Resveratrol attenuated estrogen-deficient-induced cardiac dysfunction: role of AMPK, SIRT1, and mitochondrial function
Topics: AMPK; Resveratrol; SIRT1; heart; ischemia; mitochondrion
2016; Health E!ects of Alkaline Diet and Water, Reduction of Digestive-tract Bacterial Load, and Earthing
Topics: Metabolic acidosis, chronic inflammation, alkaline diet, alkaline water, metabolic syndrom, hypertension, earthing, digestive-tract bacterial load
2016; Efficacy of an orally administered combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women
Topics: Curcumin; Estrogen; Glycosaminoglycans; Quercetin; Urinary tract infections
Topics: Collagen; Obesity; estrogen deficiency
2015: Comparative effects of vitamin C on the effects of local anesthetics ropivacaine, bupivacaine, and lidocaine on human chondrocytes
Topics: Chondrocytes; Vitamin C; Local anesthetics; Ropivacaine; Bupivacaine; Lidocaine
Topics: knee; articular cartilage; chondroprotection; nutraceutical
Topics: Vitamin D, 25-hydroxyvitamin D3, cardiovascular disease
2015; Glycine improves biochemical and biomechanical properties following inflammation of the achilles tendon
Topics: achilles tendon; extracellular matrix; glycine; inflammatory process; tendinopathy.
2015; Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin resistance and glycaemia in 9-10 year-old children
Topics: Vitamin C, glycaemia, diabetes type 2, insulin resistens
2014: Whey protein hydrolysate augments tendon and muscle hypertrophy independent of resistance exercise contraction mode
Topics: strength training, patellar tendon, eccentric training, concentric training, rate of force development, isotonic.
Topics: ascorbic acid, antioxidant, body weight, oxidative stress
Topics: Orally HA, HA supplement
Topics: Antioxidative therapy; Atherogenesis; Cardiovascular disease; Homocysteine; Neopterin; Nitric oxide; Oxidative stress; Tetrahydrobiopterin; Tryptophan; Vitamins.
2013: Local vitamin-C Injection Reduced Tendon Adhesion in a Chicken Model of Flexor Digitorum Profundus Tendon Injury
Topics: Vitamin C, healing tendon, adhesion,
2013; Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection
Topics: Vitamin C, immune response, antiviral, influenza A, interferon alfa/beta
2013; Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies
Topics: antioxidants • diet • meta-analysis • prevention • stroke
Topics: Vitamin C, Atherosclerosis, Diabetes, Immunity, Cancer, Infertility, Heavy metal toxicity
2013; Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin-C deficient mice
Topics: ascorbate, gulonolactone oxidase knockout mice, metastasis, tumor growth, melanoma B16F0, breast cancer 4T1, collagen I and IV, matrix metalloproteinase-9, apoptosis, interleukin-6
2013; A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C
Topics: ascorbate; ascorbic acid; human; plasma; urine; semen; leukocytes; skeletal muscle
2012: Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism
Topics: Nutrition, Muscle, Anabolic intramuscular signaling, Hypertrophy
Topics: intestinal microbiota, inflammation, disease susceptibility, nutrition
Topics: ascorbate transport; brain; dehydroascorbate; glutamate; neurons; SVCT2
2011: Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial
Delayed gadolinium enhanced,
Magnetic resonance imaging,
Topics: acne, probiotics, intestinal microflora, gut-brain-skin, bacteriotherapy
Topics: Ascorbic acid, biosynthesis, GLO gene, L-gulono-gamma-lactone oxidase, pseudogene, vitamin C.
Topics: Metabolic acidosis, alkaline diet, metabolic syndrom
2010; The straight line hypothesis elaborated: Case reference obesity, an argument for acidosis, oxidative stress, and disease conglomeration
Topics: Oxidative stress, acidosis, obesity, proton imbalance
2009; Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options
Topics: ROS, oxidative stress, antioxidants, neurodegenerative diseases, rns, amyloid, catalase, phagocytes
Transplasma membrane electron transport
Topics: ascorbic acid, vitamins, supplementation, scurvy
Topics: Vitamin C, ascorbic acid, angiogenesis
2007: Mechanical Stimulation Increases Collagen Type I and Collagen Type III Gene Expression of Stem Cell–Collagen Sponge Constructs for Patellar Tendon Repair
Topics: Collagen type I, collagen type III, mechanical load, patellar tendon
2007: Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial
Topics: Osteoarthritis, vitamin C, ascorbate, nutrition, intra articular
2007; Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo
Topics: ascorbic acid ” cancer ” vitamin C ” pharmacokinetics
Topics: tendon metabolism; tendon mechanical function; connective tissue;
Topics: articular cartilage, essential fatty acids, glucosamine sulphate, glucose transport, nutraceutical, nutrition, osteoarthritis, osteochondritis, vitamin C
Topics: metabolism, matrix protein, stable-isotope tracer, proline, bone turnover, nutrition
2003: Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen
Topics: Collagen hydrolysate; Collagen secretion;
Chondrocyte metabolism; Type II collagen; Cell culture
2003;Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus
Topics: Diabetes, endothelium, insulin, oxidative stress, post-prandial lipaemia.
Topics: Vitamin C, ascorbic acid
1999: Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL)
Topics: gelatin hydrolysate; peptide absorption; organ distribution; cartilage; mice (C57/BL)
Topics: Vitamin C, animals, antioxidant, ascorbic acid
1990; Immunological evidence for the accumulation of lipoprotein(a) in the atherosclerotic lesion of the hypoascorbemic guinea pig
Topics: Ascorbic acid, Vitamin C, atherosclerosis
1978; Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer
Topics: vitamin C, ascorbate, cancer
Topics: vitamin C, syntesis, animal, stress, histamin
Dr Heike Jäger, Professor Karl Arfors and innovator Hans Bohlin presented the latest research regarding Fascia, inflammation and Fascia treatment in Stockholm, May 2017.
Fascia is a system of flexible connective tissue encapsulating everything in the body. If the system is running smoothly, all is fine, but when some parts become stiff, tense or inflamed, there will be consequences.
Exclusive interview with Gil Headly explaining how Fascia changes the perspective on how we look at the body at the 2015 Fascia Research Congress in Washington DC.
Fascia is a network of connective tissue, without beginning and end, which encloses everything in the whole body, from muscles and bones, to organs and cells. But what does that mean?
A lot of injuries after a long break might not be that unusual – but why do so many female athletes suffer from cruciate ligament injuries?
Get a deeper introduction to new Fascia Research with the 2018 German documentary “The mysterious world under the skin”.
At the 2015 Fascia Research Congress in Washington DC, Tom Myers, the author of Anatomy Trains, gives a short introduction to Fascia and how new research changes the way we look at pain and discomfort.
You probably know that the immune system is our defensive wall protecting us from the threats from the outside world – but do you know how it works and how to boost it?
The concept of Fascia Lines is a great way to understand how the body functions and how treatment can be optimized to increase mobility and functionality. The main principle is that muscles, no matter what they do individually, also affect tissues throughout the entire body.
In the 70s when the orthopedic surgeon Dr. Stephen Levin was at a natural history museum and saw the wires holding up the neck of a dinosaur, he did not get the picture to go together. How could his neck have been held up originally?
In 2015 veterinary Vibeke S Elbrønd published the first report on Fascia and horses. To make that happen she had to learn all there was regarding fascia, she had to become a fascia expert.
David Lesondak is a structural integrator and a myofascial specialist who has been working for many years trying to explain what fascia is, as well as the benefits you get from treating different problems with fascia treatment. In an interview at the Fascia Research Congress in Berlin 2018, he describes the basics of what fascia is and what challenges it is facing in the strive for recognition in the medical field.
Tom Myers is perhaps best known for his book Anatomy Trains, where he describes the Myofascial lines which help us understand movement and functions of the body
Exclusive interview with Dr Stephen Levin, the worlds leading expert on Biotensegrity, at the Fascia Research Congress 2015.
Strolling under the skin is a fascinating journey inside a living body. With small camcorders, Dr. Jean Claeude Guimberteau has managed to capture how Fasica actually looks in a living human body.
By beginning to see the body as something that is alive, and not something that is dead, we have been able to begin to notice other things.
New research leads to insights and by looking at the body in a completely new way we get new perspectives and explanations to symptoms and diseases. At the 2015 Joint Conference on Acupuncture, Oncology and Fascia in Boston, research was presented regarding Fascia and Cancer
On the Fascia Guide FAQ we have gathered the most common questions and answers about Fascia. Is there anything you would like to know? Visit the page and submit your question.
Here are three major reasons why the Fascia’s central importance to the body’s functionality is not nousehold knowledge. It might be helpful to bare these in mind when relating to current and previous research.
The new discoveries and knowledge about Fascia has taken us back to an observing stage – we have to investigate our surroundings to get an understanding for what to measure.
In 2015 veterinary Vibeke S Elbrønd published the first report on Fascia and horses. Through autopsy she found that the horse has the same kind of chains and networks of connective tissue through the body, as found in humans.
What is Fascia? New research shows that it is more than the layer around the muscles. It is a network without beginning or end, from the skin, through the entire body, to the smallest cell.
Look at a ballet dancer, a gymnast or a drummer and study their movement, feeling, timing, it is easy to be fascinated by how fast it is. Fascia helps us understand how the body is able to function in such an incredible way.
What we do know for sure is that the abundance of sugar has a negative effect on the fascia and makes it less elastic. Stress also affects the fascia in a disadvantageous way
From Newton, to Einstein, to the new wildfire of Fascia Research. How do we understand things from a different perspective?
David Lesondak describes how stretching the fascia is vital for rehabilitation from injury at the 2018 Fascia Research Congress in Berlin
In early 2013, a German documentary was broadcast based on the latest research on the Fascia. It provides a very basic introduction for newcomers. To help you get a quick overview of Fascia, we have cut together a 10 minute version.
New research shows that low back pain is caused by inflammation in the Fascia. But why are we getting low back pain and what happens in our body when we get back pain?
To truly understand Fascia, you must understand the whole. But how do you do that if you have trained all your life to divide and separate?
Recently, a German researcher showed that the connective tissue in a human transports 15 l of water in 48 hours, which is a relatively large amount compared to for example the amount of blood and the lymphatic system.
Fascia research has sparked an ongoing global revolution in the anatomical research field. In The Fascia Guide Research Database we have gathered hundreds of research articles about fascia.
Fascia is a new perspective, a completely new way of looking at the body, a new way of conducting research and a new way of understanding the world. So how do you learn to understand Fascia?
Vitamin C is good for the immune system, but did you know that it also supports tissue regeneration or that we use up 7 times more Vitamin C during stress?
Fascia research has sparked a wildfire of new insights that are challenging conventional belief about how the body works – and the latest insights are presented at the 2018 Fascia Research Congress in Berlin.
One of the best ways to keep yourself healthy, free from pain and injuries is to take care of your Fascia. Here are 9 tips on how to take care of your Fascia.
What do we know about the Fascias function and what affects the Fascias ability to rebuild – and how can we use that knowledge in our everyday lives?