Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer, 1978
Topics: vitamin C, ascorbate, cancer
Authors: EWAN CAMERON AND LINUS PAULING
A study has been made of the survival times of 100 terminal cancer patients who were given supplemental ascorbate, usually 10 g/day, as part of their routine management and 1000 matched controls, similar patients who had received the same treatment except for the ascorbate. The two sets of patients were in part the same as those used in our earlier study [Cameron, E. & Pauling, L. (1976) Proc. Natl. Acad. Sci. USA 73, 3685-3689]. Tests confirm that the ascorbate-treated patients and the matched controls are representative subpopulations of the same population of “untreatable” patients. Survival times were measured not only from the date of “untreatability” but also from the precisely known date of first hospital attendance for the cancer that eventually reached the terminal stage. The ascorbate-treated patients were found to have a mean survival time about 300 days greater than that of the controls. Survival times greater than 1 yr after the date of untreatability were observed for 22% of the ascorbate-treated patients and for 0.4% of the controls. The mean survival time of these 22 ascorbate-treated patients is 2.4 yr after reaching the apparently terminal stage; 8 of the ascorbate-treated patients are still alive, with a mean survival time after untreatability of 3.5 yr.
Related research articles
2021; The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review
Topics: Fat free mass; Gelatin; Joint health; Joint pain; Muscle damage; Protein
2021; Menopause, Ultraviolet Exposure, and Low Water Intake Potentially Interact with the Genetic Variants Related to Collagen Metabolism Involved in Skin Wrinkle Risk in Middle-Aged Women
Topics: COL17A1; EGFR; MMP16; UV exposure; genetic variants; wrinkle.
2020: Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress
Topics: collagen; estrogen; oxidative stress; phytoestrogens; skin aging; water content
2020; Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse
Topics: Epidemiology; Pelvic Organ Prolapse; physiopathology
2019: Stress Relaxation and Targeted Nutrition to Treat Patellar Tendinopathy
Topics: exercise, jumper’s knee, loading, rehabilitation, tendon
2019: Rehabilitation and nutrition protocols for optimising return to play from traditional ACL reconstruction in elite rugby union players: A case study
Topics: ACL, collagen, rehabilitation, nutrition
2019: Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans
Topics: Nutrition, tissue protein synthesis rate, amino acid content in tissues
2019: Plasma Amino Acid Concentrations After the Ingestion of Dairy and Collagen Proteins, in Healthy Active Males
Topics: leucine, proline, glycine, hydroxyproline, tendon, ligament, connective tissue, athlete
2019: Intra-articular effects of combined xenogenous serum rich in growth factors (SRGF) and vitamin C on histopathology grading and staging of osteoarthritis in rat model
Topics: Osteoarthritis; SRGF; Monosodium iodoacetate; Vitamin C; Histopathology
2019: Effects of season long participation on ACL volume in female intercollegiate soccer athletes
Topics: Anterior cruciate ligament, collagen, intense physical training, volumetric changes in ligament, pre- to post season changes in ligament,
2019: Effects of Different Vitamin C-enriched Collagen Derivatives on Collagen Synthesis
Topics: gelatin, N-terminal peptide of procollagen, exercise, musculoskeletal, injury
2019: A Systematic Review of the Morphology and Function of the Sacrotuberous Ligament
Topics: anatomy; pelvis; ligament; review
2019; Mechanics and structural stability of the collagen triple helix
Topics: Collagen, triple helix
2018; Bone turnover markers after the menopause: T-score approach
Topics: Bone mineral density; Bone turnover markers; Menopause; Osteoporosis
2017: Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis
Topics: bone, exercise, ligament, tendon, inury prevention, return to play
2017: Sensitivity of ACL Volume and T2* Relaxation Time to Magnetic Resonance Imaging Scan Conditions
Topics: ACL; MRI; T2* relaxometry
2017: Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments
Topics: training, minimizing injury, return to play, supplementation
2017; Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease
Topics: Bruck syndrome; Collagen; Ehlers–Danlos syndrome; connective tissue disorders; fibrosis; lysyl hydroxylation; osteogenesis imperfecta; prolyl hydroxylation.
2017; Amino acid composition in determination of collagen origin and ssessment of physical factors effects
Topics: Hydroxyproline, Bone collagen, Fish skin collagen, Irradiation, Polymer
2016: Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways
Topics: chondrocyte; interleukin; matrix metalloproteinase; osteoarthritis; vitamin C
2016: Stretch-induced network reconfiguration of collagen fibres in the human facet capsular ligament
Topics: collagen, fibre realignment, facet capsular
ligament, community detection,
2015: Osmotic pressure induced tensile forces in tendon collagen
Topics: water, collagen, osmotic pressure
2015: Estrogen inhibits lysyl oxidase and decreases mechanical function in engineered ligaments
Topics: ACL; exercise; tendon; ultimate tensile strength
2015: Comparative effects of vitamin C on the effects of local anesthetics ropivacaine, bupivacaine, and lidocaine on human chondrocytes
Topics: Chondrocytes; Vitamin C; Local anesthetics; Ropivacaine; Bupivacaine; Lidocaine
2015: Collagen network strengthening following cyclic tensile loading
Topics: collagen network, mechanical adaptation, tissue remodelling
2015: Chondroprotection and the Prevention of Osteoarthritis Progression of the Knee
Topics: knee; articular cartilage; chondroprotection; nutraceutical
2014: Whey protein hydrolysate augments tendon and muscle hypertrophy independent of resistance exercise contraction mode
Topics: strength training, patellar tendon, eccentric training, concentric training, rate of force development, isotonic.
2014: Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: Candidate amino acids involved in Advanced Glycation End-products
Topics: Advanced glycation end-products; Ageing; Atomistic simulations; Collagen; Crosslinks; Diabetes.
2014; The role of collagen crosslinks in ageing and diabetes – the good, the bad, and the ugly
Topics: collagen, advanced glycation endproducts, crosslinks, tendon mechanics, diabetes, ageing
2013: Local vitamin-C Injection Reduced Tendon Adhesion in a Chicken Model of Flexor Digitorum Profundus Tendon Injury
Topics: Vitamin C, healing tendon, adhesion,
2013; The myofibroblast matrix: implications for tissue repair and fibrosis
Topics: ECM; myofibroblast; fibrosis
2012: Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism
Topics: Nutrition, Muscle, Anabolic intramuscular signaling, Hypertrophy
2012; Mathematical model of fiber orientation in anisotropic fascia layers at large displacements
Topics: Fascial; Reinforcement; Collagen fibers; Re-orientation; Tension
2011: Optimizing an Intermittent Stretch Paradigm Using ERK1/2 Phosphorylation Results in Increased Collagen Synthesis in Engineered Ligaments
Topics: collagen synthesis, ERK 1/2 phosphorylation, intermittent stretch
2011: Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial
Delayed gadolinium enhanced,
Magnetic resonance imaging,
2011; The presence of physiological stress shielding in the degenerative cycle of musculoskeletal disorders
Topics: Fascia; Musculoskeletal; Cerebral palsy; Remodeling; Stress shielding
2011; Structure and function of the skeletal muscle extracellular matrix
Topics: Skeletal muscle; extracellular matrix; collagen; biomechanics; fibrosis
2010: Tendon and ligament fibrillar crimps give rise to left-handed helices of collagen fibrils in both planar and helical crimps
Topics: collagen handedness; fibrillar crimp; helical crimps; ligament; planar crimps; tendon
Topics: Collagens; Extracellular matrix; Fibrils; FACITs; Basement membrane
2009: Effect of Loading on the Organization of the Collagen Fibril Network in Juvenile Equine Articular Cartilage
Topics: cartilage; collagen fibril; loading; parallelism; orientation
2008: Fibroblast mechanics in three-dimensional collagen matrices
Topics: Fascia; Tension; Contraction; Migration; Growth factor; Regulation
2007: Mechanical Stimulation Increases Collagen Type I and Collagen Type III Gene Expression of Stem Cell–Collagen Sponge Constructs for Patellar Tendon Repair
Topics: Collagen type I, collagen type III, mechanical load, patellar tendon
2007: Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial
Topics: Osteoarthritis, vitamin C, ascorbate, nutrition, intra articular
2007: Expression of collagen and related growth factors in rat tendon and skeletal muscle in response to specific contraction types
Topics: collagen synthesis, contraction type, concentric, eccentric, isometric
2006: Low-intensity tensile loading increases intratendinous glucose uptake
in the Achilles tendon
Topics: tendon metabolism; tendon mechanical function; connective tissue;
2006: Dynamic Shear Stimulation of Bovine Cartilage Biosynthesis of Proteoglycan 4
Topics: Cartilage, proteoglycans, PRG4, dynamic shear stress, static compression
2005: Nutraceutical Therapies for Degenerative Joint Diseases: A Critical Review
Topics: articular cartilage, essential fatty acids, glucosamine sulphate, glucose transport, nutraceutical, nutrition, osteoarthritis, osteochondritis, vitamin C
2005: Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions
Topics: eccentric; concentric; resistance exercise; z-band streaming
2005: Human Bone Collagen Synthesis Is a Rapid, Nutritionally Modulated Process
Topics: metabolism, matrix protein, stable-isotope tracer, proline, bone turnover, nutrition
2004: Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading
Topics: ECM, collagen, tendons, skeletal muscles, mechanical loading
2003: Stress shielding of patellar tendon: effect on small-diameter collagen fibrils in a rabbit model
Topics: Stress shielding · Patellar tendon · Collagen fibril
diameter · Ultrastructure
2003: Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen
Topics: Collagen hydrolysate; Collagen secretion;
Chondrocyte metabolism; Type II collagen; Cell culture
2002: Effects of Biomechanical Stress on Bones in Animals
Topics: Exercise; Mechanotransduction; Sensitivity; Saturation; Adaptation
2002: Detection of changes in cartilage water content using MRI T2-mapping in vivo
Topics: Early osteoarthritis, Water content, MRI, T2-mapping
2000: Effect of Mechanical Load on Articular Cartilage Collagen Structure: A Scanning Electron-Microscopic Study
Topics: Morphology; Loading, mechanical; Collagen fibers; Scanning electron microscopy; Cryofixation; Freeze
1999: Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL)
Topics: gelatin hydrolysate; peptide absorption; organ distribution; cartilage; mice (C57/BL)
1979: THE INFLUENCE OF MECHANICAL FORCES ON THE GLYCOSAMINOGLYCAN CONTENT OF THE RABBIT FLEXOR DIGITORUM PROFUNDUS TENDON
Topics: ECM, GAG, collagen, deep digital flexor tendon, loading
Training for strengthened Fascia
Exercise increases collagen production in tendons, ligaments and all Fascia. To stimulate collagen formation in tendons and ligaments, it doesn’t matter if the exercise is eccentric (muscle contraction during extension) or concentric (muscle contraction during shortening).
The discovery of a new cell at the 2018 Fascia Research Congress in Berlin
Fascia research has sparked a wildfire of new insights that are challenging conventional belief about how the body works – and the latest insights are presented at the 2018 Fascia Research Congress in Berlin.
Biotensegrity: How did the dinosaurs handle the pressure of gravity?
In the 70s when the orthopedic surgeon Dr. Stephen Levin was at a natural history museum and saw the wires holding up the neck of a dinosaur, he did not get the picture to go together. How could his neck have been held up originally?
Fluid flow in the fascia & how it is affected by treatment & vibrations
Recently, a German researcher showed that the connective tissue in a human transports 15 l of water in 48 hours, which is a relatively large amount compared to for example the amount of blood and the lymphatic system.
Strolling under the skin: How does it look inside a living body?
Strolling under the skin is a fascinating journey inside a living body. With small camcorders, Dr. Jean Claeude Guimberteau has managed to capture how Fasica actually looks in a living human body.
To understand Fascia we need to cross the bridge & see things from another perspective
Exclusive interview with Gil Headly explaining how Fascia changes the perspective on how we look at the body at the 2015 Fascia Research Congress in Washington DC.
We have been preparing our whole lives to NOT be able to understand the importance of fascia
To truly understand Fascia, you must understand the whole. But how do you do that if you have trained all your life to divide and separate?
How do we learn to understand Fascia?
Fascia is a new perspective, a completely new way of looking at the body, a new way of conducting research and a new way of understanding the world. So how do you learn to understand Fascia?
Fascia does not only envelope the whole body, it turns the way we look at the body upside down
At the 2015 Fascia Research Congress in Washington DC, Tom Myers, the author of Anatomy Trains, gives a short introduction to Fascia and how new research changes the way we look at pain and discomfort.
Why Fascia is still relatively unknown
Here are three major reasons why the Fascia’s central importance to the body’s functionality is not nousehold knowledge. It might be helpful to bare these in mind when relating to current and previous research.