Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology, 2015

Topics: hyaluronan, molecular size, cell signaling

Authors: Jaime M. Cyphert, Carol S. Trempus, and Stavros Garantziotis


Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the generation of hyaluronan fragments of different size and size-dependent differences in hyaluronan signaling as well as their downstream biological effects.

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