Mechanics and structural stability of the collagen triple helix, 2019
Topics: Collagen, triple helix
Authors: Michael WH Kirkness, Kathrin Lehmann and Nancy R Forde
Abstract
he primary building block of the body is collagen, which is found in the extracellular matrix and in many stress-bearing tissues such as tendon and cartilage. It provides elasticity and support to cells and tissues while influencing biological pathways including cell signaling, motility, and differentiation. Collagen’s unique triple helical structure is thought to impart mechanical stability. However, detailed experimental studies on its molecular mechanics have been only recently emerging. Here, we review the treatment of the triple helix as a homogeneous flexible rod, including bend (standard worm-like chain model), twist, and stretch deformations, and the assumption of backbone linearity. Additionally, we discuss protein-specific properties of the triple helix including sequence dependence, and relate single-molecule mechanics to collagen’s physiological context.
Related research articles
Frequently Asked Questions about Fascia
On the Fascia Guide FAQ we have gathered the most common questions and answers about Fascia. Is there anything you would like to know? Visit the page and submit your question.
Stress and sugar harms fascia functions
What we do know for sure is that the abundance of sugar has a negative effect on the fascia and makes it less elastic. Stress also affects the fascia in a disadvantageous way
Understanding Fascia in 10 minutes – the must see German documentary
In early 2013, a German documentary was broadcast based on the latest research on the Fascia. It provides a very basic introduction for newcomers. To help you get a quick overview of Fascia, we have cut together a 10 minute version.
Fascia Lines are the intersections of the body
The concept of Fascia Lines is a great way to understand how the body functions and how treatment can be optimized to increase mobility and functionality. The main principle is that muscles, no matter what they do individually, also affect tissues throughout the entire body.
Get the lymph flow!
Keep the flow of lymph alive! What can I do to increase the lymph flow?
Fascia in Horses – Danish veterinary exploring uncharted territory
In 2015 veterinary Vibeke S Elbrønd published the first report on Fascia and horses. Through autopsy she found that the horse has the same kind of chains and networks of connective tissue through the body, as found in humans.
The immune system: How it works & how to boost it
You probably know that the immune system is our defensive wall protecting us from the threats from the outside world – but do you know how it works and how to boost it?
The discovery of a new cell at the 2018 Fascia Research Congress in Berlin
Fascia research has sparked a wildfire of new insights that are challenging conventional belief about how the body works – and the latest insights are presented at the 2018 Fascia Research Congress in Berlin.
Why do so many female football players suffer from cruciate ligament injuries?
A lot of injuries after a long break might not be that unusual – but why do so many female athletes suffer from cruciate ligament injuries?
The mysterious world under the skin – German Fascia Documentary from 2018
Get a deeper introduction to new Fascia Research with the 2018 German documentary “The mysterious world under the skin”.