Immunological evidence for the accumulation of lipoprotein(a) in the atherosclerotic lesion of the hypoascorbemic guinea pig, 1990
Topics: Ascorbic acid, Vitamin C, atherosclerosis
Authors: M Rath & L Pauling
Lipoprotein(a) [Lp(a)] is an extremely atherogenic lipoprotein. Lp(a) has been found in the plasma of humans and other primates, but until now only in a few other species. The mechanism by which it exerts its atherogenicity is still poorly understood. We observed that Lp(a) has been found in the plasma of several species unable to synthesize ascorbate and not in other species. We have now detected apoprotein(a) in the plasma of the guinea pig. We induced atherosclerosis in this animal by dietary ascorbate depletion and, using SDS/PAGE and subsequent immunoblotting, we identified Lp(a) as accumulating in the atherosclerotic plaque. Most importantly, adequate amounts of ascorbate (40 mg per kg of body weight per day) prevent the development of atherosclerotic lesions in this animal model and the accumulation of Lp(a) in the arterial wall. We suggest an analogous mechanism in humans because of the similarity between guinea pigs and humans with respect to both the lack of endogenous ascorbate production and the role of Lp(a) in human atherosclerosis.
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Fascia Lines are the intersections of the body
The concept of Fascia Lines is a great way to understand how the body functions and how treatment can be optimized to increase mobility and functionality. The main principle is that muscles, no matter what they do individually, also affect tissues throughout the entire body.
Why do so many female football players suffer from cruciate ligament injuries?
A lot of injuries after a long break might not be that unusual – but why do so many female athletes suffer from cruciate ligament injuries?
Frequently Asked Questions about Fascia
On the Fascia Guide FAQ we have gathered the most common questions and answers about Fascia. Is there anything you would like to know? Visit the page and submit your question.
Fascia helps us understand the body as a whole
Look at a ballet dancer, a gymnast or a drummer and study their movement, feeling, timing, it is easy to be fascinated by how fast it is. Fascia helps us understand how the body is able to function in such an incredible way.
What is fascia and in what way does fascia change the whole way of looking at the body?
Fascia is a network of connective tissue, without beginning and end, which encloses everything in the whole body, from muscles and bones, to organs and cells. But what does that mean?
Get the lymph flow!
Keep the flow of lymph alive! What can I do to increase the lymph flow?
Fascia loads and unloads pressure
What do we know about the Fascias function and what affects the Fascias ability to rebuild – and how can we use that knowledge in our everyday lives?
Stretching the fascia is vital when recovering from injury
David Lesondak describes how stretching the fascia is vital for rehabilitation from injury at the 2018 Fascia Research Congress in Berlin
We have been preparing our whole lives to NOT be able to understand the importance of fascia
To truly understand Fascia, you must understand the whole. But how do you do that if you have trained all your life to divide and separate?
The influence of mechanical forces on Fascia?
Connective tissue / fascia is an incredibly adaptable and plastic tissue. It is transformed, remodeled and strengthened or weakened according to the mechanical stimulation (load) to which it is exposed. If we don’t move, the tissue will diminish.