Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials, 2017
Topics: Vitamin C, insulin resistens, glycaemic control
Authors: AW Ashor, AD Werner, J Lara, ND Willis, JC Mathers and M Siervo
Randomised controlled trials (RCTs) have observed contrasting results on the effects of vitamin C on circulating biomarkers of glycaemic and insulin regulation. We conducted a systematic review and meta-analysis of RCTs testing the effect of vitamin C administration on glucose, HbA1c and insulin concentrations. Four databases (PubMed, Embase, Scopus and Cochrane Library) were used to retrieve RCTs published from inception until April 2016 and testing the effects of vitamin C in adult participants. The screening of 2008 articles yielded 22 eligible studies (937 participants). Overall, vitamin C did not modify glucose, HbA1c and insulin concentrations. However, subgroup analyses showed that vitamin C significantly reduced glucose concentrations (-0.44 mmol/l, 95% CI: -0.81, -0.07, P=0.01) in patients with type 2 diabetes and in interventions with a duration greater than 30 days (-0.53%, 95% CI: -0.79, -0.10, P=0.02). Vitamin C administration had greater effects on fasting (-13.63 pmol/l, 95% CI: -22.73, -4.54, P
Related research articles
2021; The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review
Topics: Fat free mass; Gelatin; Joint health; Joint pain; Muscle damage; Protein
2021; Menopause, Ultraviolet Exposure, and Low Water Intake Potentially Interact with the Genetic Variants Related to Collagen Metabolism Involved in Skin Wrinkle Risk in Middle-Aged Women
Topics: COL17A1; EGFR; MMP16; UV exposure; genetic variants; wrinkle.
2020: Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress
Topics: collagen; estrogen; oxidative stress; phytoestrogens; skin aging; water content
2020; Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse
Topics: Epidemiology; Pelvic Organ Prolapse; physiopathology
2019: Stress Relaxation and Targeted Nutrition to Treat Patellar Tendinopathy
Topics: exercise, jumper’s knee, loading, rehabilitation, tendon
2019: Rehabilitation and nutrition protocols for optimising return to play from traditional ACL reconstruction in elite rugby union players: A case study
Topics: ACL, collagen, rehabilitation, nutrition
2019: Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans
Topics: Nutrition, tissue protein synthesis rate, amino acid content in tissues
2019: Plasma Amino Acid Concentrations After the Ingestion of Dairy and Collagen Proteins, in Healthy Active Males
Topics: leucine, proline, glycine, hydroxyproline, tendon, ligament, connective tissue, athlete
2019: Intra-articular effects of combined xenogenous serum rich in growth factors (SRGF) and vitamin C on histopathology grading and staging of osteoarthritis in rat model
Topics: Osteoarthritis; SRGF; Monosodium iodoacetate; Vitamin C; Histopathology
2019: Effects of season long participation on ACL volume in female intercollegiate soccer athletes
Topics: Anterior cruciate ligament, collagen, intense physical training, volumetric changes in ligament, pre- to post season changes in ligament,
2019: Effects of Different Vitamin C-enriched Collagen Derivatives on Collagen Synthesis
Topics: gelatin, N-terminal peptide of procollagen, exercise, musculoskeletal, injury
2019: A Systematic Review of the Morphology and Function of the Sacrotuberous Ligament
Topics: anatomy; pelvis; ligament; review
2019; Mechanics and structural stability of the collagen triple helix
Topics: Collagen, triple helix
2018; Bone turnover markers after the menopause: T-score approach
Topics: Bone mineral density; Bone turnover markers; Menopause; Osteoporosis
2017: Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis
Topics: bone, exercise, ligament, tendon, inury prevention, return to play
2017: Sensitivity of ACL Volume and T2* Relaxation Time to Magnetic Resonance Imaging Scan Conditions
Topics: ACL; MRI; T2* relaxometry
2017: Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments
Topics: training, minimizing injury, return to play, supplementation
2017; Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease
Topics: Bruck syndrome; Collagen; Ehlers–Danlos syndrome; connective tissue disorders; fibrosis; lysyl hydroxylation; osteogenesis imperfecta; prolyl hydroxylation.
2017; Amino acid composition in determination of collagen origin and ssessment of physical factors effects
Topics: Hydroxyproline, Bone collagen, Fish skin collagen, Irradiation, Polymer
2016: Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways
Topics: chondrocyte; interleukin; matrix metalloproteinase; osteoarthritis; vitamin C
2016: Stretch-induced network reconfiguration of collagen fibres in the human facet capsular ligament
Topics: collagen, fibre realignment, facet capsular
ligament, community detection,
2015: Osmotic pressure induced tensile forces in tendon collagen
Topics: water, collagen, osmotic pressure
2015: Estrogen inhibits lysyl oxidase and decreases mechanical function in engineered ligaments
Topics: ACL; exercise; tendon; ultimate tensile strength
2015: Comparative effects of vitamin C on the effects of local anesthetics ropivacaine, bupivacaine, and lidocaine on human chondrocytes
Topics: Chondrocytes; Vitamin C; Local anesthetics; Ropivacaine; Bupivacaine; Lidocaine
2015: Collagen network strengthening following cyclic tensile loading
Topics: collagen network, mechanical adaptation, tissue remodelling
2015: Chondroprotection and the Prevention of Osteoarthritis Progression of the Knee
Topics: knee; articular cartilage; chondroprotection; nutraceutical
2014: Whey protein hydrolysate augments tendon and muscle hypertrophy independent of resistance exercise contraction mode
Topics: strength training, patellar tendon, eccentric training, concentric training, rate of force development, isotonic.
2014: Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: Candidate amino acids involved in Advanced Glycation End-products
Topics: Advanced glycation end-products; Ageing; Atomistic simulations; Collagen; Crosslinks; Diabetes.
2014; The role of collagen crosslinks in ageing and diabetes – the good, the bad, and the ugly
Topics: collagen, advanced glycation endproducts, crosslinks, tendon mechanics, diabetes, ageing
2013: Local vitamin-C Injection Reduced Tendon Adhesion in a Chicken Model of Flexor Digitorum Profundus Tendon Injury
Topics: Vitamin C, healing tendon, adhesion,
2013; The myofibroblast matrix: implications for tissue repair and fibrosis
Topics: ECM; myofibroblast; fibrosis
2012: Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism
Topics: Nutrition, Muscle, Anabolic intramuscular signaling, Hypertrophy
2012; Mathematical model of fiber orientation in anisotropic fascia layers at large displacements
Topics: Fascial; Reinforcement; Collagen fibers; Re-orientation; Tension
2011: Optimizing an Intermittent Stretch Paradigm Using ERK1/2 Phosphorylation Results in Increased Collagen Synthesis in Engineered Ligaments
Topics: collagen synthesis, ERK 1/2 phosphorylation, intermittent stretch
2011: Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial
Delayed gadolinium enhanced,
Magnetic resonance imaging,
2011; The presence of physiological stress shielding in the degenerative cycle of musculoskeletal disorders
Topics: Fascia; Musculoskeletal; Cerebral palsy; Remodeling; Stress shielding
2011; Structure and function of the skeletal muscle extracellular matrix
Topics: Skeletal muscle; extracellular matrix; collagen; biomechanics; fibrosis
2010: Tendon and ligament fibrillar crimps give rise to left-handed helices of collagen fibrils in both planar and helical crimps
Topics: collagen handedness; fibrillar crimp; helical crimps; ligament; planar crimps; tendon
Topics: Collagens; Extracellular matrix; Fibrils; FACITs; Basement membrane
2009: Effect of Loading on the Organization of the Collagen Fibril Network in Juvenile Equine Articular Cartilage
Topics: cartilage; collagen fibril; loading; parallelism; orientation
2008: Fibroblast mechanics in three-dimensional collagen matrices
Topics: Fascia; Tension; Contraction; Migration; Growth factor; Regulation
2007: Mechanical Stimulation Increases Collagen Type I and Collagen Type III Gene Expression of Stem Cell–Collagen Sponge Constructs for Patellar Tendon Repair
Topics: Collagen type I, collagen type III, mechanical load, patellar tendon
2007: Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial
Topics: Osteoarthritis, vitamin C, ascorbate, nutrition, intra articular
2007: Expression of collagen and related growth factors in rat tendon and skeletal muscle in response to specific contraction types
Topics: collagen synthesis, contraction type, concentric, eccentric, isometric
2006: Low-intensity tensile loading increases intratendinous glucose uptake
in the Achilles tendon
Topics: tendon metabolism; tendon mechanical function; connective tissue;
2006: Dynamic Shear Stimulation of Bovine Cartilage Biosynthesis of Proteoglycan 4
Topics: Cartilage, proteoglycans, PRG4, dynamic shear stress, static compression
2005: Nutraceutical Therapies for Degenerative Joint Diseases: A Critical Review
Topics: articular cartilage, essential fatty acids, glucosamine sulphate, glucose transport, nutraceutical, nutrition, osteoarthritis, osteochondritis, vitamin C
2005: Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions
Topics: eccentric; concentric; resistance exercise; z-band streaming
2005: Human Bone Collagen Synthesis Is a Rapid, Nutritionally Modulated Process
Topics: metabolism, matrix protein, stable-isotope tracer, proline, bone turnover, nutrition
2004: Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading
Topics: ECM, collagen, tendons, skeletal muscles, mechanical loading
2003: Stress shielding of patellar tendon: effect on small-diameter collagen fibrils in a rabbit model
Topics: Stress shielding · Patellar tendon · Collagen fibril
diameter · Ultrastructure
2003: Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen
Topics: Collagen hydrolysate; Collagen secretion;
Chondrocyte metabolism; Type II collagen; Cell culture
2002: Effects of Biomechanical Stress on Bones in Animals
Topics: Exercise; Mechanotransduction; Sensitivity; Saturation; Adaptation
2002: Detection of changes in cartilage water content using MRI T2-mapping in vivo
Topics: Early osteoarthritis, Water content, MRI, T2-mapping
2000: Effect of Mechanical Load on Articular Cartilage Collagen Structure: A Scanning Electron-Microscopic Study
Topics: Morphology; Loading, mechanical; Collagen fibers; Scanning electron microscopy; Cryofixation; Freeze
1999: Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL)
Topics: gelatin hydrolysate; peptide absorption; organ distribution; cartilage; mice (C57/BL)
1979: THE INFLUENCE OF MECHANICAL FORCES ON THE GLYCOSAMINOGLYCAN CONTENT OF THE RABBIT FLEXOR DIGITORUM PROFUNDUS TENDON
Topics: ECM, GAG, collagen, deep digital flexor tendon, loading
Inflammation in Fascia causes pain – new discoveries presented in Stockholm
Dr Heike Jäger, Professor Karl Arfors and innovator Hans Bohlin presented the latest research regarding Fascia, inflammation and Fascia treatment in Stockholm, May 2017.
7 things you should now about Vitamin C
Vitamin C is good for the immune system, but did you know that it also supports tissue regeneration or that we use up 7 times more Vitamin C during stress?
Why Fascia is still relatively unknown
Here are three major reasons why the Fascia’s central importance to the body’s functionality is not nousehold knowledge. It might be helpful to bare these in mind when relating to current and previous research.
The influence of mechanical forces on Fascia?
Connective tissue / fascia is an incredibly adaptable and plastic tissue. It is transformed, remodeled and strengthened or weakened according to the mechanical stimulation (load) to which it is exposed. If we don’t move, the tissue will diminish.
Biotensegrity: How did the dinosaurs handle the pressure of gravity?
In the 70s when the orthopedic surgeon Dr. Stephen Levin was at a natural history museum and saw the wires holding up the neck of a dinosaur, he did not get the picture to go together. How could his neck have been held up originally?
The importance of vitamin C in pregnancy, childbirth and jaundice in newborns.
Vitamin C has many different actions in the body. It is a coenzyme, which assist in various physiological processes in the body and it is a powerful antioxidant.
Fascia does not only envelope the whole body, it turns the way we look at the body upside down
At the 2015 Fascia Research Congress in Washington DC, Tom Myers, the author of Anatomy Trains, gives a short introduction to Fascia and how new research changes the way we look at pain and discomfort.
Can you heal osteoarthritis?
The function of the articular cartilage is to reduce friction between the two articular cartilage surfaces and facilitate sliding when the joint moves, and to absorb the load when the joint is exposed to pressure, compression
Get the lymph flow!
Keep the flow of lymph alive! What can I do to increase the lymph flow?
The immune system: How it works & how to boost it
You probably know that the immune system is our defensive wall protecting us from the threats from the outside world – but do you know how it works and how to boost it?