Densification: Hyaluronan Aggregation in Different Human Organs, 2022
Topics: aggregation; blood vessels; densification; eye; fascia; hyaluronan; kidney; liver; lung; muscle; skin.
Authors: Antonio Stecco, Mary Cowman, Nina Pirri, Preeti Raghavan, Carmelo Pirri
Abstract
Hyaluronan (HA) has complex biological roles that have catalyzed clinical interest in several fields of medicine. In this narrative review, we provide an overview of HA aggregation, also called densification, in human organs. The literature suggests that HA aggregation can occur in the liver, eye, lung, kidney, blood vessel, muscle, fascia, skin, pancreatic cancer and malignant melanoma. In all these organs, aggregation of HA leads to an increase in extracellular matrix viscosity, causing stiffness and organ dysfunction. Fibrosis, in some of these organs, may also occur as a direct consequence of densification in the long term. Specific imaging evaluation, such dynamic ultrasonography, elasto-sonography, elasto-MRI and T1ρ MRI can permit early diagnosis to enable the clinician to organize the treatment plan and avoid further progression of the pathology and dysfunction.
Related research articles
Anatomy Trains by Tom Myers helps us understand functions of movement
Tom Myers is perhaps best known for his book Anatomy Trains, where he describes the Myofascial lines which help us understand movement and functions of the body
Fascia does not only envelope the whole body, it turns the way we look at the body upside down
At the 2015 Fascia Research Congress in Washington DC, Tom Myers, the author of Anatomy Trains, gives a short introduction to Fascia and how new research changes the way we look at pain and discomfort.
Fluid flow in the fascia & how it is affected by treatment & vibrations
Recently, a German researcher showed that the connective tissue in a human transports 15 l of water in 48 hours, which is a relatively large amount compared to for example the amount of blood and the lymphatic system.
Fascia Lines are the intersections of the body
The concept of Fascia Lines is a great way to understand how the body functions and how treatment can be optimized to increase mobility and functionality. The main principle is that muscles, no matter what they do individually, also affect tissues throughout the entire body.
We have been preparing our whole lives to NOT be able to understand the importance of fascia
To truly understand Fascia, you must understand the whole. But how do you do that if you have trained all your life to divide and separate?
Fascia: New research changes the way we look at pain
From Newton, to Einstein, to the new wildfire of Fascia Research. How do we understand things from a different perspective?
The discovery of a new cell at the 2018 Fascia Research Congress in Berlin
Fascia research has sparked a wildfire of new insights that are challenging conventional belief about how the body works – and the latest insights are presented at the 2018 Fascia Research Congress in Berlin.
Fascia or interstitium – what’s the difference?
Fascia eller interstitium? Fascian eller interstitium är kroppens arkitektoniska byggnadsstomme med sitt kontinuerliga flöde, som en amerikansk forskargrupp nu alltså anser vara kroppens största organ.
What causes back pain?
New research shows that low back pain is caused by inflammation in the Fascia. But why are we getting low back pain and what happens in our body when we get back pain?
Strolling under the skin: How does it look inside a living body?
Strolling under the skin is a fascinating journey inside a living body. With small camcorders, Dr. Jean Claeude Guimberteau has managed to capture how Fasica actually looks in a living human body.