Cell tension, matrix mechanics, and cancer development, 2005
Topics: mechanotransduction, cancer, extracellular matrix, cytoskeleton
Authors: Sui Huang and Donald E. Ingber
Oncologists often diagnose cancer based on a change of tissue stiffness sensed by palpation, yet cancer researchers generally focus on biochemical signaling mechanisms. Tumors are more rigid because they have a stiffer extracellular matrix. A new study shows that this alteration of matrix mechanics activates integrins, which not only promotes mitogenic signaling through Erk but also cell contractility through Rho, which can further increase matrix stiffness. This establishes a positive feedback loop that switches on the malignant phenotype in mammary epithelial cells. This mechanical “autocrine loop” brings solid-state mechanotransduction on a par with oncogenic signaling pathways in malignant transformation.
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Fascia is a new perspective, a completely new way of looking at the body, a new way of conducting research and a new way of understanding the world. So how do you learn to understand Fascia?
We have been preparing our whole lives to NOT be able to understand the importance of fascia
To truly understand Fascia, you must understand the whole. But how do you do that if you have trained all your life to divide and separate?
Fascia Lines are the intersections of the body
The concept of Fascia Lines is a great way to understand how the body functions and how treatment can be optimized to increase mobility and functionality. The main principle is that muscles, no matter what they do individually, also affect tissues throughout the entire body.
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David Lesondak is a structural integrator and a myofascial specialist who has been working for many years trying to explain what fascia is, as well as the benefits you get from treating different problems with fascia treatment. In an interview at the Fascia Research Congress in Berlin 2018, he describes the basics of what fascia is and what challenges it is facing in the strive for recognition in the medical field.
Biotensegrity: How did the dinosaurs handle the pressure of gravity?
In the 70s when the orthopedic surgeon Dr. Stephen Levin was at a natural history museum and saw the wires holding up the neck of a dinosaur, he did not get the picture to go together. How could his neck have been held up originally?
Understanding Fascia in 10 minutes – the must see German documentary
In early 2013, a German documentary was broadcast based on the latest research on the Fascia. It provides a very basic introduction for newcomers. To help you get a quick overview of Fascia, we have cut together a 10 minute version.
The importance of vitamin C in pregnancy, childbirth and jaundice in newborns.
Vitamin C has many different actions in the body. It is a coenzyme, which assist in various physiological processes in the body and it is a powerful antioxidant.
Why do so many female football players suffer from cruciate ligament injuries?
A lot of injuries after a long break might not be that unusual – but why do so many female athletes suffer from cruciate ligament injuries?
Fascia Guide Research Database
Fascia research has sparked an ongoing global revolution in the anatomical research field. In The Fascia Guide Research Database we have gathered hundreds of research articles about fascia.