An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle, 2005
Topics: myofascial trigger points; musculoskeletal pain; microdialysis; soft tissue pain; pressure pain threshold
Authors: Jay P. Shah, Terry M. Phillips, Jerome V. Danoff and Lynn H. Gerber
Abstract
Myofascial pain associated with myofascial trigger points (MTrPs) is a common cause of nonarticular musculoskeletal pain. Although the presence of MTrPs can be determined by soft tissue palpation, little is known about the mechanisms and biochemical milieu associated with persistent muscle pain. A microanalytical system was developed to measure the in vivo biochemical milieu of muscle in near real time at the subnanogram level of concentration. The system includes a microdialysis needle capable of continuously collecting extremely small samples (approximately 0.5 microl) of physiological saline after exposure to the internal tissue milieu across a 105-microm-thick semi-permeable membrane. This membrane is positioned 200 microm from the tip of the needle and permits solutes of
Related research articles
Fascia as a flow – a new way of explaining the body’s function
By beginning to see the body as something that is alive, and not something that is dead, we have been able to begin to notice other things.
The discovery of a new cell at the 2018 Fascia Research Congress in Berlin
Fascia research has sparked a wildfire of new insights that are challenging conventional belief about how the body works – and the latest insights are presented at the 2018 Fascia Research Congress in Berlin.
What is Fascia? Connective tissue in a system with no beginning & no end
What is Fascia? New research shows that it is more than the layer around the muscles. It is a network without beginning or end, from the skin, through the entire body, to the smallest cell.
Fascia in Horses – Danish veterinary exploring uncharted territory
In 2015 veterinary Vibeke S Elbrønd published the first report on Fascia and horses. Through autopsy she found that the horse has the same kind of chains and networks of connective tissue through the body, as found in humans.
Biotensegrity: How did the dinosaurs handle the pressure of gravity?
In the 70s when the orthopedic surgeon Dr. Stephen Levin was at a natural history museum and saw the wires holding up the neck of a dinosaur, he did not get the picture to go together. How could his neck have been held up originally?
Fascia Expert: “An explosion of new research in the last 10 years”
In 2015 veterinary Vibeke S Elbrønd published the first report on Fascia and horses. To make that happen she had to learn all there was regarding fascia, she had to become a fascia expert.
Fascia Lines are the intersections of the body
The concept of Fascia Lines is a great way to understand how the body functions and how treatment can be optimized to increase mobility and functionality. The main principle is that muscles, no matter what they do individually, also affect tissues throughout the entire body.
New Fascia Research has taken us back to an observing stage
The new discoveries and knowledge about Fascia has taken us back to an observing stage – we have to investigate our surroundings to get an understanding for what to measure.
Fluid flow in the fascia & how it is affected by treatment & vibrations
Recently, a German researcher showed that the connective tissue in a human transports 15 l of water in 48 hours, which is a relatively large amount compared to for example the amount of blood and the lymphatic system.
Stretching the fascia is vital when recovering from injury
David Lesondak describes how stretching the fascia is vital for rehabilitation from injury at the 2018 Fascia Research Congress in Berlin